Francisella tularensis subsp. novicida isolated from a human in Arizona

Dawn N. Birdsell; Tasha Stewart; Amy J. Vogler; Elisabeth Lawaczeck; Alisa Diggs; Tammy L. Sylvester; Jordan L. Buchhagen; Raymond K. Auerbach; Paul Keim; David M. Wagner

doi:10.1186/1756-0500-2-223

Francisella tularensis subsp. novicida isolated from a human in Arizona

Dawn N. Birdsell, Tasha Stewart, Amy J. Vogler, Elisabeth Lawaczeck, Alisa Diggs, Tammy L. Sylvester, Jordan L. Buchhagen, Raymond K. Auerbach, Paul Keim, David M. Wagner

Biological Sciences

Research output: Contribution to journal › Article › peer-review

33 Scopus citations

Abstract

Background. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in virulence and geographical distribution are recognized:tularensis (type A), holarctica (type B), mediasiatica, and novicida. Because of the Select Agent status and differences in virulence and geographical location, the molecular analysis of any clinical case of tularemia is of particular interest. We analyzed an unusual Francisella clinical isolate from a human infection in Arizona using multiple DNA-based approaches. Findings. We report that the isolate is F. tularensis subsp. novicida, a subspecies that is rarely isolated. Conclusion. The rarity of this novicida subspecies in clinical settings makes each case study important for our understanding of its role in disease and its genetic relationship with other F. tularensis subspecies.

Original language	English (US)
Article number	223
Journal	BMC Research Notes
Volume	2
DOIs	https://doi.org/10.1186/1756-0500-2-223
State	Published - 2009

ASJC Scopus subject areas

General Biochemistry, Genetics and Molecular Biology

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title = "Francisella tularensis subsp. novicida isolated from a human in Arizona",

abstract = "Background. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in virulence and geographical distribution are recognized:tularensis (type A), holarctica (type B), mediasiatica, and novicida. Because of the Select Agent status and differences in virulence and geographical location, the molecular analysis of any clinical case of tularemia is of particular interest. We analyzed an unusual Francisella clinical isolate from a human infection in Arizona using multiple DNA-based approaches. Findings. We report that the isolate is F. tularensis subsp. novicida, a subspecies that is rarely isolated. Conclusion. The rarity of this novicida subspecies in clinical settings makes each case study important for our understanding of its role in disease and its genetic relationship with other F. tularensis subspecies.",

author = "Birdsell, {Dawn N.} and Tasha Stewart and Vogler, {Amy J.} and Elisabeth Lawaczeck and Alisa Diggs and Sylvester, {Tammy L.} and Buchhagen, {Jordan L.} and Auerbach, {Raymond K.} and Paul Keim and Wagner, {David M.}",

note = "Funding Information: This work was funded by the Department of Homeland Security Science and Technology Directorate (NBCH2070001 and HSHQDC-08-C-00158), the Pacific Southwest Regional Center of Excellence (AI065359), and the Cowden Endowment in Microbiology at Northern Arizona University. Note that the use of products/names does not constitute endorsement by the Department of Homeland Security of the United States. We thank Jean-nine Petersen and James Schupp for helpful discussions.",

year = "2009",

doi = "10.1186/1756-0500-2-223",

language = "English (US)",

volume = "2",

journal = "BMC Research Notes",

issn = "1756-0500",

publisher = "BioMed Central Ltd.",

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TY - JOUR

T1 - Francisella tularensis subsp. novicida isolated from a human in Arizona

AU - Birdsell, Dawn N.

AU - Stewart, Tasha

AU - Vogler, Amy J.

AU - Lawaczeck, Elisabeth

AU - Diggs, Alisa

AU - Sylvester, Tammy L.

AU - Buchhagen, Jordan L.

AU - Auerbach, Raymond K.

AU - Keim, Paul

AU - Wagner, David M.

N1 - Funding Information: This work was funded by the Department of Homeland Security Science and Technology Directorate (NBCH2070001 and HSHQDC-08-C-00158), the Pacific Southwest Regional Center of Excellence (AI065359), and the Cowden Endowment in Microbiology at Northern Arizona University. Note that the use of products/names does not constitute endorsement by the Department of Homeland Security of the United States. We thank Jean-nine Petersen and James Schupp for helpful discussions.

PY - 2009

Y1 - 2009

N2 - Background. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in virulence and geographical distribution are recognized:tularensis (type A), holarctica (type B), mediasiatica, and novicida. Because of the Select Agent status and differences in virulence and geographical location, the molecular analysis of any clinical case of tularemia is of particular interest. We analyzed an unusual Francisella clinical isolate from a human infection in Arizona using multiple DNA-based approaches. Findings. We report that the isolate is F. tularensis subsp. novicida, a subspecies that is rarely isolated. Conclusion. The rarity of this novicida subspecies in clinical settings makes each case study important for our understanding of its role in disease and its genetic relationship with other F. tularensis subspecies.

AB - Background. Francisella tularensis is the etiologic agent of tularemia and is classified as a select agent by the Centers for Disease Control and Prevention. Currently four known subspecies of F. tularensis that differ in virulence and geographical distribution are recognized:tularensis (type A), holarctica (type B), mediasiatica, and novicida. Because of the Select Agent status and differences in virulence and geographical location, the molecular analysis of any clinical case of tularemia is of particular interest. We analyzed an unusual Francisella clinical isolate from a human infection in Arizona using multiple DNA-based approaches. Findings. We report that the isolate is F. tularensis subsp. novicida, a subspecies that is rarely isolated. Conclusion. The rarity of this novicida subspecies in clinical settings makes each case study important for our understanding of its role in disease and its genetic relationship with other F. tularensis subspecies.

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Francisella tularensis subsp. novicida isolated from a human in Arizona

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