Formation and stabilization of fluorescent gold nanoclusters using small molecules

Yuping Bao, Hsin Chih Yeh, Chang Zhong, Sergei A. Ivanov, Jaswinder K. Sharma, Michael L. Neidig, Dung M. Vu, Andrew P. Shreve, R. Brian Dyer, James H. Werner, Jennifer S. Martinez

Research output: Contribution to journalArticlepeer-review

90 Scopus citations


Biological molecular imaging and sensing requires fluorophores that are not only stable and bright, but also small enough to allow the unencumbered observation of the movement of proteins. Toward this goal, we have studied the formation of fluorescent metallic gold nanoclusters stabilized by small molecule ligands. The morpholine and piperazine backbones of Good's buffers were used to template fluorescent clusters, through a process of etching of nanoparticles first formed in the reaction. The clusters are found to be subnanometer sized, with nanosecond fluorescence lifetimes and as bright, or brighter, than the commercial dye norharmane.

Original languageEnglish (US)
Pages (from-to)15879-15882
Number of pages4
JournalJournal of Physical Chemistry C
Issue number38
StatePublished - Sep 30 2010
Externally publishedYes

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • General Energy
  • Physical and Theoretical Chemistry
  • Surfaces, Coatings and Films


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