Fine-scale identification of the most likely source of a human plague infection

Rebecca E. Colman; Amy J. Vogler; Jennifer L. Lowell; Kenneth L. Gage; Christina Morway; Pamela J. Reynolds; Paul Ettestad; Paul Keim; Michael Y. Kosoy; David M. Wagner

doi:10.3201/eid1510.090188

Fine-scale identification of the most likely source of a human plague infection

Rebecca E. Colman, Amy J. Vogler, Jennifer L. Lowell, Kenneth L. Gage, Christina Morway, Pamela J. Reynolds, Paul Ettestad, Paul Keim, Michael Y. Kosoy, David M. Wagner

Biological Sciences

Research output: Contribution to journal › Article › peer-review

25 Scopus citations

Abstract

We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.

Original language	English (US)
Pages (from-to)	1623-1625
Number of pages	3
Journal	Emerging infectious diseases
Volume	15
Issue number	10
DOIs	https://doi.org/10.3201/eid1510.090188
State	Published - Oct 2009

ASJC Scopus subject areas

Epidemiology
Microbiology (medical)
Infectious Diseases

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10.3201/eid1510.090188

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title = "Fine-scale identification of the most likely source of a human plague infection",

abstract = "We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.",

author = "Colman, {Rebecca E.} and Vogler, {Amy J.} and Lowell, {Jennifer L.} and Gage, {Kenneth L.} and Christina Morway and Reynolds, {Pamela J.} and Paul Ettestad and Paul Keim and Kosoy, {Michael Y.} and Wagner, {David M.}",

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AU - Colman, Rebecca E.

AU - Vogler, Amy J.

AU - Lowell, Jennifer L.

AU - Gage, Kenneth L.

AU - Morway, Christina

AU - Reynolds, Pamela J.

AU - Ettestad, Paul

AU - Keim, Paul

AU - Kosoy, Michael Y.

AU - Wagner, David M.

PY - 2009/10

Y1 - 2009/10

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AB - We describe an analytic approach to provide fine-scale discrimination among multiple infection source hypotheses. This approach uses mutation-rate data for rapidly evolving multiple locus variable-number tandem repeat loci in probabilistic models to identify the most likely source. We illustrate the utility of this approach using data from a North American human plague investigation.

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Fine-scale identification of the most likely source of a human plague infection

Abstract

ASJC Scopus subject areas

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