@inproceedings{c9d228baa9b141258ea2152689fba52e,
title = "Femtosecond third-order sum frequency and four-wave mixing imaging",
abstract = "Various contrast mechanisms in imaging applications in biological and material sciences are of great importance for multimodal sample visualization. Nonlinear-optical interactions in the sample provide multitude of possibilities to imaging with different contrasts, including sensitivity to chemically-specific vibrational signatures. Cubic order nonlinearity is present in all materials since it does not require broken inversion symmetry. Cubic non- linearity offers several useful interaction modalities, including vibrationally resonant ones, such as third-order sum-frequency generation (TSFG) and four-wave mixing (FWM), which we explore in this work using femtosecond lasers in a laser-scanning all-reflective microscope. We observe strong dependence of image contrast on delay between interacting pulses and the frequency of the mid-IR laser relative to the CH vibrational mode of the sample. Images of oil-water interfaces demonstrate striking visual contrast and impressive signal-to-noise ratio in our system. Pathways to expand TSFG and FWM imaging onto biological samples are explored.",
keywords = "Four-wave mixing, Liquid interface, Nonlinear imaging, Third-order sum-frequency generation",
author = "Evan Perillo and {Lisa Phipps}, M. and Martinez, {Jennifer S.} and Anatoly Efimov",
note = "Funding Information: Research presented in this article was supported by the Laboratory Directed Research and Development program of Los Alamos National Laboratory under project number 20170249ER. The work was in part supported by the Center for Integrated Nanotechnologies, a U.S. DOE BES user facility. Publisher Copyright: {\textcopyright} 2020 SPIE.; Multiscale Imaging and Spectroscopy 2020 ; Conference date: 01-02-2020 Through 02-02-2020",
year = "2020",
doi = "10.1117/12.2546261",
language = "English (US)",
series = "Progress in Biomedical Optics and Imaging - Proceedings of SPIE",
publisher = "SPIE",
editor = "Campagnola, {Paul J.} and Maitland, {Kristen C.} and Roblyer, {Darren M.}",
booktitle = "Multiscale Imaging and Spectroscopy",
}