Abstract
Cefiderocol is a siderophore cephalosporin designed mainly for treatment of infections caused by b-lactam and multidrug-resistant Gram-negative bacteria. Burkholderia pseudomallei clinical isolates are usually highly cefiderocol susceptible, with in vitro resistance found in a few isolates. Resistance in clinical B. pseudomallei isolates from Australia is caused by a hitherto uncharacterized mechanism. We show that, like in other Gram-negatives, the PiuA outer membrane receptor plays a major role in cefiderocol nonsusceptibility in isolates from Malaysia.
Original language | English (US) |
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Journal | Antimicrobial Agents and Chemotherapy |
Volume | 67 |
Issue number | 6 |
DOIs | |
State | Published - Jun 2023 |
Keywords
- Burkholderia pseudomallei
- cefiderocol
- resistance
ASJC Scopus subject areas
- Pharmacology
- Pharmacology (medical)
- Infectious Diseases