Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Jason T. Ladner; Michael R. Wiley; Suzanne Mate; Gytis Dudas; Karla Prieto; Sean Lovett; Elyse R. Nagle; Brett Beitzel; Merle L. Gilbert; Lawrence Fakoli; Joseph W. Diclaro; Randal J. Schoepp; Joseph Fair; Jens H. Kuhn; Lisa E. Hensley; Daniel J. Park; Pardis C. Sabeti; Andrew Rambaut; Mariano Sanchez-Lockhart; Fatorma K. Bolay; Jeffrey R. Kugelman; Gustavo Palacios

doi:10.1016/j.chom.2015.11.008

Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Jason T. Ladner, Michael R. Wiley, Suzanne Mate, Gytis Dudas, Karla Prieto, Sean Lovett, Elyse R. Nagle, Brett Beitzel, Merle L. Gilbert, Lawrence Fakoli, Joseph W. Diclaro, Randal J. Schoepp, Joseph Fair, Jens H. Kuhn, Lisa E. Hensley, Daniel J. Park, Pardis C. Sabeti, Andrew Rambaut, Mariano Sanchez-Lockhart, Fatorma K. BolayJeffrey R. Kugelman, Gustavo Palacios

Research output: Contribution to journal › Article › peer-review

74 Scopus citations

Abstract

Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

Original language	English (US)
Pages (from-to)	659-669
Number of pages	11
Journal	Cell Host and Microbe
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2015.11.008
State	Published - Dec 1 2015
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

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10.1016/j.chom.2015.11.008

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Ladner, J. T., Wiley, M. R., Mate, S., Dudas, G., Prieto, K., Lovett, S., Nagle, E. R., Beitzel, B., Gilbert, M. L., Fakoli, L., Diclaro, J. W., Schoepp, R. J., Fair, J., Kuhn, J. H., Hensley, L. E., Park, D. J., Sabeti, P. C., Rambaut, A., Sanchez-Lockhart, M., ... Palacios, G. (2015). Evolution and Spread of Ebola Virus in Liberia, 2014-2015. Cell Host and Microbe, 18(6), 659-669. https://doi.org/10.1016/j.chom.2015.11.008

Ladner, JT, Wiley, MR, Mate, S, Dudas, G, Prieto, K, Lovett, S, Nagle, ER, Beitzel, B, Gilbert, ML, Fakoli, L, Diclaro, JW, Schoepp, RJ, Fair, J, Kuhn, JH, Hensley, LE, Park, DJ, Sabeti, PC, Rambaut, A, Sanchez-Lockhart, M, Bolay, FK, Kugelman, JR & Palacios, G 2015, 'Evolution and Spread of Ebola Virus in Liberia, 2014-2015', Cell Host and Microbe, vol. 18, no. 6, pp. 659-669. https://doi.org/10.1016/j.chom.2015.11.008

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title = "Evolution and Spread of Ebola Virus in Liberia, 2014-2015",

abstract = "Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.",

author = "Ladner, {Jason T.} and Wiley, {Michael R.} and Suzanne Mate and Gytis Dudas and Karla Prieto and Sean Lovett and Nagle, {Elyse R.} and Brett Beitzel and Gilbert, {Merle L.} and Lawrence Fakoli and Diclaro, {Joseph W.} and Schoepp, {Randal J.} and Joseph Fair and Kuhn, {Jens H.} and Hensley, {Lisa E.} and Park, {Daniel J.} and Sabeti, {Pardis C.} and Andrew Rambaut and Mariano Sanchez-Lockhart and Bolay, {Fatorma K.} and Kugelman, {Jeffrey R.} and Gustavo Palacios",

note = "Funding Information: This work was supported by the Defense Threat Reduction Agency, Global Biosurveillance Technology Initiative, Global Emerging Infections System and US Agency for International Development. A.R. was supported by EU Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no. 278433-PREDEMICS. The content of this publication does not necessarily reflect the views or policies of the US Army, the US Dept of Defense, the US Dept of Health and Human Services or the institutions/companies affiliated with the authors. J.H.K. performed this work as an employee of Tunnell Government Services, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with the National Institute of Allergy and Infectious Diseases (Contract No. HHSN272200700016I). Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

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doi = "10.1016/j.chom.2015.11.008",

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T1 - Evolution and Spread of Ebola Virus in Liberia, 2014-2015

AU - Ladner, Jason T.

AU - Wiley, Michael R.

AU - Mate, Suzanne

AU - Dudas, Gytis

AU - Prieto, Karla

AU - Lovett, Sean

AU - Nagle, Elyse R.

AU - Beitzel, Brett

AU - Gilbert, Merle L.

AU - Fakoli, Lawrence

AU - Diclaro, Joseph W.

AU - Schoepp, Randal J.

AU - Fair, Joseph

AU - Kuhn, Jens H.

AU - Hensley, Lisa E.

AU - Park, Daniel J.

AU - Sabeti, Pardis C.

AU - Rambaut, Andrew

AU - Sanchez-Lockhart, Mariano

AU - Bolay, Fatorma K.

AU - Kugelman, Jeffrey R.

AU - Palacios, Gustavo

N1 - Funding Information: This work was supported by the Defense Threat Reduction Agency, Global Biosurveillance Technology Initiative, Global Emerging Infections System and US Agency for International Development. A.R. was supported by EU Seventh Framework Programme (FP7/2007-2013) under Grant Agreement no. 278433-PREDEMICS. The content of this publication does not necessarily reflect the views or policies of the US Army, the US Dept of Defense, the US Dept of Health and Human Services or the institutions/companies affiliated with the authors. J.H.K. performed this work as an employee of Tunnell Government Services, Inc., a subcontractor to Battelle Memorial Institute under its prime contract with the National Institute of Allergy and Infectious Diseases (Contract No. HHSN272200700016I). Publisher Copyright: © 2015 Elsevier Inc.

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

AB - Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

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Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Abstract

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