Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Jason T. Ladner; Michael R. Wiley; Suzanne Mate; Gytis Dudas; Karla Prieto; Sean Lovett; Elyse R. Nagle; Brett Beitzel; Merle L. Gilbert; Lawrence Fakoli; Joseph W. Diclaro; Randal J. Schoepp; Joseph Fair; Jens H. Kuhn; Lisa E. Hensley; Daniel J. Park; Pardis C. Sabeti; Andrew Rambaut; Mariano Sanchez-Lockhart; Fatorma K. Bolay; Jeffrey R. Kugelman; Gustavo Palacios

doi:10.1016/j.chom.2015.11.008

Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Jason T. Ladner, Michael R. Wiley, Suzanne Mate, Gytis Dudas, Karla Prieto, Sean Lovett, Elyse R. Nagle, Brett Beitzel, Merle L. Gilbert, Lawrence Fakoli, Joseph W. Diclaro, Randal J. Schoepp, Joseph Fair, Jens H. Kuhn, Lisa E. Hensley, Daniel J. Park, Pardis C. Sabeti, Andrew Rambaut, Mariano Sanchez-Lockhart, Fatorma K. BolayJeffrey R. Kugelman, Gustavo Palacios

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

Original language	English (US)
Pages (from-to)	659-669
Number of pages	11
Journal	Cell Host and Microbe
Volume	18
Issue number	6
DOIs	https://doi.org/10.1016/j.chom.2015.11.008
State	Published - Dec 1 2015
Externally published	Yes

ASJC Scopus subject areas

Parasitology
Microbiology
Virology

Access to Document

10.1016/j.chom.2015.11.008

Cite this

Ladner, J. T., Wiley, M. R., Mate, S., Dudas, G., Prieto, K., Lovett, S., Nagle, E. R., Beitzel, B., Gilbert, M. L., Fakoli, L., Diclaro, J. W., Schoepp, R. J., Fair, J., Kuhn, J. H., Hensley, L. E., Park, D. J., Sabeti, P. C., Rambaut, A., Sanchez-Lockhart, M., ... Palacios, G. (2015). Evolution and Spread of Ebola Virus in Liberia, 2014-2015. Cell Host and Microbe, 18(6), 659-669. https://doi.org/10.1016/j.chom.2015.11.008

Ladner, JT, Wiley, MR, Mate, S, Dudas, G, Prieto, K, Lovett, S, Nagle, ER, Beitzel, B, Gilbert, ML, Fakoli, L, Diclaro, JW, Schoepp, RJ, Fair, J, Kuhn, JH, Hensley, LE, Park, DJ, Sabeti, PC, Rambaut, A, Sanchez-Lockhart, M, Bolay, FK, Kugelman, JR & Palacios, G 2015, 'Evolution and Spread of Ebola Virus in Liberia, 2014-2015', Cell Host and Microbe, vol. 18, no. 6, pp. 659-669. https://doi.org/10.1016/j.chom.2015.11.008

@article{b64fef38f569418b925a0bddf223717a,

title = "Evolution and Spread of Ebola Virus in Liberia, 2014-2015",

abstract = "Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.",

author = "Ladner, {Jason T.} and Wiley, {Michael R.} and Suzanne Mate and Gytis Dudas and Karla Prieto and Sean Lovett and Nagle, {Elyse R.} and Brett Beitzel and Gilbert, {Merle L.} and Lawrence Fakoli and Diclaro, {Joseph W.} and Schoepp, {Randal J.} and Joseph Fair and Kuhn, {Jens H.} and Hensley, {Lisa E.} and Park, {Daniel J.} and Sabeti, {Pardis C.} and Andrew Rambaut and Mariano Sanchez-Lockhart and Bolay, {Fatorma K.} and Kugelman, {Jeffrey R.} and Gustavo Palacios",

note = "Publisher Copyright: {\textcopyright} 2015 Elsevier Inc.",

year = "2015",

month = dec,

day = "1",

doi = "10.1016/j.chom.2015.11.008",

language = "English (US)",

volume = "18",

pages = "659--669",

journal = "Cell Host and Microbe",

issn = "1931-3128",

publisher = "Cell Press",

number = "6",

}

TY - JOUR

T1 - Evolution and Spread of Ebola Virus in Liberia, 2014-2015

AU - Ladner, Jason T.

AU - Wiley, Michael R.

AU - Mate, Suzanne

AU - Dudas, Gytis

AU - Prieto, Karla

AU - Lovett, Sean

AU - Nagle, Elyse R.

AU - Beitzel, Brett

AU - Gilbert, Merle L.

AU - Fakoli, Lawrence

AU - Diclaro, Joseph W.

AU - Schoepp, Randal J.

AU - Fair, Joseph

AU - Kuhn, Jens H.

AU - Hensley, Lisa E.

AU - Park, Daniel J.

AU - Sabeti, Pardis C.

AU - Rambaut, Andrew

AU - Sanchez-Lockhart, Mariano

AU - Bolay, Fatorma K.

AU - Kugelman, Jeffrey R.

AU - Palacios, Gustavo

PY - 2015/12/1

Y1 - 2015/12/1

N2 - Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

AB - Summary The 2013-present Western African Ebola virus disease (EVD) outbreak is the largest ever recorded with >28,000 reported cases. Ebola virus (EBOV) genome sequencing has played an important role throughout this outbreak; however, relatively few sequences have been determined from patients in Liberia, the second worst-affected country. Here, we report 140 EBOV genome sequences from the second wave of the Liberian outbreak and analyze them in combination with 782 previously published sequences from throughout the Western African outbreak. While multiple early introductions of EBOV to Liberia are evident, the majority of Liberian EVD cases are consistent with a single introduction, followed by spread and diversification within the country. Movement of the virus within Liberia was widespread, and reintroductions from Liberia served as an important source for the continuation of the already ongoing EVD outbreak in Guinea. Overall, little evidence was found for incremental adaptation of EBOV to the human host.

UR - http://www.scopus.com/inward/record.url?scp=84951139771&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84951139771&partnerID=8YFLogxK

U2 - 10.1016/j.chom.2015.11.008

DO - 10.1016/j.chom.2015.11.008

M3 - Article

C2 - 26651942

AN - SCOPUS:84951139771

SN - 1931-3128

VL - 18

SP - 659

EP - 669

JO - Cell Host and Microbe

JF - Cell Host and Microbe

IS - 6

ER -

Evolution and Spread of Ebola Virus in Liberia, 2014-2015

Abstract

ASJC Scopus subject areas

Access to Document

Other files and links

Fingerprint

Cite this