Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

S. Qiu; X. Xu; Y. Wang; G. Yang; Z. Wang; H. Wang; L. Zhang; N. Liu; C. Chen; W. Liu; J. Li; W. Su; L. Jia; L. Wang; H. Jin; P. Keim; Z. Yuan; L. Huang; H. Song

doi:10.1111/j.1469-0691.2012.03768.x

Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

S. Qiu, X. Xu, Y. Wang, G. Yang, Z. Wang, H. Wang, L. Zhang, N. Liu, C. Chen, W. Liu, J. Li, W. Su, L. Jia, L. Wang, H. Jin, P. Keim, Z. Yuan, L. Huang, H. Song

Biological Sciences

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16 Scopus citations

Abstract

We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

Original language	English (US)
Pages (from-to)	E95-E98
Journal	Clinical Microbiology and Infection
Volume	18
Issue number	4
DOIs	https://doi.org/10.1111/j.1469-0691.2012.03768.x
State	Published - Apr 2012

Keywords

Banding pattern
Ciprofloxacin resistance
Genetic diversity
Sequence type
Shigella flexneri subserotype 1c

ASJC Scopus subject areas

Microbiology (medical)
Infectious Diseases

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10.1111/j.1469-0691.2012.03768.x

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Qiu, S., Xu, X., Wang, Y., Yang, G., Wang, Z., Wang, H., Zhang, L., Liu, N., Chen, C., Liu, W., Li, J., Su, W., Jia, L., Wang, L., Jin, H., Keim, P., Yuan, Z., Huang, L., & Song, H. (2012). Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China. Clinical Microbiology and Infection, 18(4), E95-E98. https://doi.org/10.1111/j.1469-0691.2012.03768.x

Qiu, S, Xu, X, Wang, Y, Yang, G, Wang, Z, Wang, H, Zhang, L, Liu, N, Chen, C, Liu, W, Li, J, Su, W, Jia, L, Wang, L, Jin, H, Keim, P, Yuan, Z, Huang, L & Song, H 2012, 'Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China', Clinical Microbiology and Infection, vol. 18, no. 4, pp. E95-E98. https://doi.org/10.1111/j.1469-0691.2012.03768.x

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title = "Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China",

abstract = "We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.",

keywords = "Banding pattern, Ciprofloxacin resistance, Genetic diversity, Sequence type, Shigella flexneri subserotype 1c",

author = "S. Qiu and X. Xu and Y. Wang and G. Yang and Z. Wang and H. Wang and L. Zhang and N. Liu and C. Chen and W. Liu and J. Li and W. Su and L. Jia and L. Wang and H. Jin and P. Keim and Z. Yuan and L. Huang and H. Song",

note = "Funding Information: This work was funded by the Mega-projects of Science and Technology Research of China (No. 2012ZX10004215-001-004) and the National Natural Science Foundation of China (No. 31000589 and 81001267). ",

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AU - Xu, X.

AU - Wang, Y.

AU - Yang, G.

AU - Wang, Z.

AU - Wang, H.

AU - Zhang, L.

AU - Liu, N.

AU - Chen, C.

AU - Liu, W.

AU - Li, J.

AU - Su, W.

AU - Jia, L.

AU - Wang, L.

AU - Jin, H.

AU - Keim, P.

AU - Yuan, Z.

AU - Huang, L.

AU - Song, H.

N1 - Funding Information: This work was funded by the Mega-projects of Science and Technology Research of China (No. 2012ZX10004215-001-004) and the National Natural Science Foundation of China (No. 31000589 and 81001267).

PY - 2012/4

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N2 - We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

AB - We report here on the first identification of Shigella flexneri subserotype 1c in China. We also report the emergence of resistance to ciprofloxacin and third-generation cephalosporins in this subserotype 1c for the first time. Isolates of seven strains circulating in China yielded three new sequence types and seven pulsed-field gel electrophoresis patterns, thus demonstrating the existence of high genetic diversity within the isolates. Overall, the seven isolates showed reduced susceptibility to ciprofloxacin; one isolate was ciprofloxacin resistant, whilst another developed resistance to ciprofloxacin, norfloxacin, cefotaxime and ceftriaxone.

KW - Banding pattern

KW - Ciprofloxacin resistance

KW - Genetic diversity

KW - Sequence type

KW - Shigella flexneri subserotype 1c

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Emergence of resistance to fluoroquinolones and third-generation cephalosporins in Shigella flexneri subserotype 1c isolates from China

Abstract

Keywords

ASJC Scopus subject areas

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