TY - JOUR
T1 - Efficacy and Safety of Massage for Osteoarthritis of the Knee
T2 - a Randomized Clinical Trial
AU - Perlman, Adam
AU - Fogerite, Susan Gould
AU - Glass, Oliver
AU - Bechard, Elizabeth
AU - Ali, Ather
AU - Njike, Valentine Y.
AU - Pieper, Carl
AU - Dmitrieva, Natalia O.
AU - Luciano, Alison
AU - Rosenberger, Lisa
AU - Keever, Teresa
AU - Milak, Carl
AU - Finkelstein, Eric A.
AU - Mahon, Gwendolyn
AU - Campanile, Giovanni
AU - Cotter, Ann
AU - Katz, David L.
N1 - Funding Information:
The team acknowledges the positive impacts and contributions of Ather Ali, ND, MPH, MHS, to their lives, with deep gratitude, love, and respect. We also thank Mary Carola (Rutgers), Michelle Pinto-Evans (Yale), and Gina Smith, MA (Yale), for coordinating study participants and entering data; Kim Turk, Kelly Cross, and Myra Blackwell (Duke); Lee Stang, Carol Nakagawara, Paula Jelly, and Susan Kmon (Yale); and Denise Ostopo-Gliozzi, Mariella Silva, and J. J. Long (Rutgers) for providing massage and light-touch interventions; Michael Patterson, PhD, DO, for developing the LT bodywork intervention; and the study subjects for their participation. This study and publication were made possible by grant number R01AT004623 from the National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health.
Funding Information:
Funding Source: This study and publication were made possible by grant number R01AT004623 from the National Center for Complementary and Integrative Health (NCCIH) at the National Institutes of Health.
Publisher Copyright:
© 2018, Society of General Internal Medicine.
PY - 2019/3/15
Y1 - 2019/3/15
N2 - Background: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. Design: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis. Participants: Five hundred fifty-one screened for eligibility, 222 adults with knee osteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed 52-week assessments. Intervention: Sixty minutes of protocolized full-body massage or light-touch. Main Measures: Primary: Western Ontario and McMaster Universities Arthritis Index. Secondary: visual analog pain scale, PROMIS Pain Interference, knee range of motion, and timed 50-ft walk. Key Results: At 8 weeks, massage significantly improved WOMAC Global scores compared to light-touch (− 8.16, 95% CI = − 13.50 to − 2.81) and usual care (− 9.55, 95% CI = − 14.66 to − 4.45). Additionally, massage improved pain, stiffness, and physical function WOMAC subscale scores compared to light-touch (p < 0.001; p = 0.04; p = 0.02, respectively) and usual care (p < 0.001; p = 0.002; p = 0.002; respectively). At 52 weeks, the omnibus test of any group difference in the change in WOMAC Global from baseline to 52 weeks was not significant (p = 0.707, df = 3), indicating no significant difference in change across groups. Adverse events were minimal. Conclusions: Efficacy of symptom relief and safety of weekly massage make it an attractive short-term treatment option for knee osteoarthritis. Longer-term biweekly dose maintained improvement, but did not provide additional benefit beyond usual care post 8-week treatment. Trial Registration: clinicaltrials.gov NCT01537484.
AB - Background: Current treatment options for knee osteoarthritis have limited effectiveness and potentially adverse side effects. Massage may offer a safe and effective complement to the management of knee osteoarthritis. Objective: Examine effects of whole-body massage on knee osteoarthritis, compared to active control (light-touch) and usual care. Design: Multisite RCT assessing the efficacy of massage compared to light-touch and usual care in adults with knee osteoarthritis, with assessments at baseline and weeks 8, 16, 24, 36, and 52. Subjects in massage or light-touch groups received eight weekly treatments, then were randomized to biweekly intervention or usual care to week 52. The original usual care group continued to week 24. Analysis was performed on an intention-to-treat basis. Participants: Five hundred fifty-one screened for eligibility, 222 adults with knee osteoarthritis enrolled, 200 completed 8-week assessments, and 175 completed 52-week assessments. Intervention: Sixty minutes of protocolized full-body massage or light-touch. Main Measures: Primary: Western Ontario and McMaster Universities Arthritis Index. Secondary: visual analog pain scale, PROMIS Pain Interference, knee range of motion, and timed 50-ft walk. Key Results: At 8 weeks, massage significantly improved WOMAC Global scores compared to light-touch (− 8.16, 95% CI = − 13.50 to − 2.81) and usual care (− 9.55, 95% CI = − 14.66 to − 4.45). Additionally, massage improved pain, stiffness, and physical function WOMAC subscale scores compared to light-touch (p < 0.001; p = 0.04; p = 0.02, respectively) and usual care (p < 0.001; p = 0.002; p = 0.002; respectively). At 52 weeks, the omnibus test of any group difference in the change in WOMAC Global from baseline to 52 weeks was not significant (p = 0.707, df = 3), indicating no significant difference in change across groups. Adverse events were minimal. Conclusions: Efficacy of symptom relief and safety of weekly massage make it an attractive short-term treatment option for knee osteoarthritis. Longer-term biweekly dose maintained improvement, but did not provide additional benefit beyond usual care post 8-week treatment. Trial Registration: clinicaltrials.gov NCT01537484.
KW - arthritis
KW - knee pain
KW - massage
KW - musculoskeletal pain
KW - osteoarthritis
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U2 - 10.1007/s11606-018-4763-5
DO - 10.1007/s11606-018-4763-5
M3 - Article
C2 - 30543021
AN - SCOPUS:85058563893
SN - 0884-8734
VL - 34
SP - 379
EP - 386
JO - Journal of General Internal Medicine
JF - Journal of General Internal Medicine
IS - 3
ER -