TY - JOUR
T1 - Effect of temperature on the CO2 sensitivity of avian intrapulmonary chemoreceptors
AU - Barnas, G. M.
AU - Hempleman, S. C.
AU - Burger, R. E.
PY - 1983/11
Y1 - 1983/11
N2 - We determined linear regressions of discharge frequency on In PCO2 of 23 intrapulmonary chemoreceptors (IPC) from eight hyperthermic, adult cockerels. At low PCO2, IPC in hyperthermic cockerels discharged slower than IPC measured in euthermic cockerels; above 25 torr PCo2, however, they discharged faster than euthermic IPC. Thus, IPC were less sensitive to PCO2 during hyperthermia. We calculate that a 1°C increase in the temperature of the lung (TL) causes the slope of the linear regression of discharge frequency on In PCO2 to be less negative by 1.5 ± 0.5 imp (sec·In PCO2)-1 and that, for any increase in TL above normal (41.5°C), the average IPC discharge frequency equals (-10.7+1.5 (TL-41.5)). (In ( PCO2 25.0)) + 3.7. This relationship may be partly responsible for the increased tidal volume and decreased respiratory frequency observed when body temperature increases during constant PaCO2.
AB - We determined linear regressions of discharge frequency on In PCO2 of 23 intrapulmonary chemoreceptors (IPC) from eight hyperthermic, adult cockerels. At low PCO2, IPC in hyperthermic cockerels discharged slower than IPC measured in euthermic cockerels; above 25 torr PCo2, however, they discharged faster than euthermic IPC. Thus, IPC were less sensitive to PCO2 during hyperthermia. We calculate that a 1°C increase in the temperature of the lung (TL) causes the slope of the linear regression of discharge frequency on In PCO2 to be less negative by 1.5 ± 0.5 imp (sec·In PCO2)-1 and that, for any increase in TL above normal (41.5°C), the average IPC discharge frequency equals (-10.7+1.5 (TL-41.5)). (In ( PCO2 25.0)) + 3.7. This relationship may be partly responsible for the increased tidal volume and decreased respiratory frequency observed when body temperature increases during constant PaCO2.
KW - Carbon dioxide
KW - Chicken
KW - Control of breathing
KW - Hyperthermia
KW - Intrapulmonary chemoreceptors
KW - Vagal afferents
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U2 - 10.1016/0034-5687(83)90060-9
DO - 10.1016/0034-5687(83)90060-9
M3 - Article
C2 - 6420861
AN - SCOPUS:0020974353
SN - 1569-9048
VL - 54
SP - 233
EP - 240
JO - Respiratory Physiology and Neurobiology
JF - Respiratory Physiology and Neurobiology
IS - 2
ER -