Distribution of serological response to burkholderia pseudomallei in swine from three provinces of Vietnam

Michael H. Norris, Hang Thi Thu Tran, Morgan A. Walker, Andrew P. Bluhm, Diansy Zincke, Trinh Thanh Trung, Nga Vu Thi, Ngoc Pham Thi, Herbert P. Schweizer, Fred Unger, Jason K. Blackburn, Nguyen Thi Thu Hang

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

(1) Background: Burkholderia pseudomallei is an environmentally mediated saprophytic pathogen that can cause severe disease in humans. It is well known that B. pseudomallei survives in tropical moist soil environments worldwide, but melioidosis is gaining recognition as a public and veterinary health issue in Vietnam. The contribution of animals to human disease is unknown, necessitating further investigation. (2) Methods: Swine sera were collected from two populations, one grazing and one commercially farmed, from three provinces in Vietnam. ELISAs utilizing B. pseudomallei capsular polysaccharide (CPS), outer polysaccharide (OPS), and Hcp1 protein were used to screen serum samples. Positive samples were mapped to the commune level. Seroprevalence calculations and pig population estimates were used to approximate number of swine exposures per commune. (3) Results: Grazing pigs from Hoa Binh had significantly higher seropositivity levels (11.4%, 95% CI: 9.7–13.1) compared to farmed pigs from Ha Tinh and Nghe An (4%, 95% CI: 3.3–4.7). Average swine seropositivity rates were ~6.3% (95% CI: 5–7.9), higher than previously identified in Vietnam (~0.88%). (4) Conclusions: Initial serological sampling identified a significant number of seropositive and potential melioidosis infections occurring in swine in Vietnam. This work is a critical step in understanding the role swine may play in the epidemiology of human melioidosis in Vietnam.

Original languageEnglish (US)
Article number5203
Pages (from-to)1-14
Number of pages14
JournalInternational Journal of Environmental Research and Public Health
Volume17
Issue number14
DOIs
StatePublished - Jul 2 2020
Externally publishedYes

Keywords

  • Burkholderia pseudomallei
  • Infectious disease
  • Interdisciplinary
  • Melioidosis
  • Outbreak
  • Swine
  • Vietnam
  • Whitmore
  • Zoonosis

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis

Fingerprint

Dive into the research topics of 'Distribution of serological response to burkholderia pseudomallei in swine from three provinces of Vietnam'. Together they form a unique fingerprint.

Cite this