Dissecting RAF Inhibitor Resistance by Structure-based Modeling Reveals Ways to Overcome Oncogenic RAS Signaling

Keyphrases

• Inhibitor Resistance 100%
• Ras Signaling 100%
• Oncogenic Ras 100%
• BRAF Inhibitor (BRAFi) 100%
• Structure-based Modeling 100%
• ERK Pathway 60%
• BRAF V600E 40%
• Post-translational Modification 20%
• Rule-based Model 20%
• Thermodynamics 20%
• Mutation Data 20%
• Tumor 20%
• Structure Model 20%
• Reduced Cell 20%
• Cell Proliferation 20%
• Colony Formation 20%
• Dynamic Model 20%
• Synergize 20%
• Targeted Inhibition 20%
• Drug Design 20%
• Inhibitor Combination 20%
• Dimerization 20%
• Best Combination 20%
• Multiple Inhibitors 20%
• RAS mutant 20%
• Thermodynamic Kinetics 20%
• Synergistic Inhibition 20%
• Drug-protein Interaction 20%
• ERK Activity 20%
• Cell Colony 20%
• Structural mutation 20%
• Model Rules 20%
• Heterodimerization 20%
• Colony Formation Assay 20%
• Cell mutation 20%
• Mutational Status 20%
• RAF Kinase 20%
• RAF Dimerization 20%
• MEK-ERK Pathway 20%
• Paradoxical Activation 20%

Biochemistry, Genetics and Molecular Biology

• Conformation 100%
• Colony Formation 100%
• Posttranslational Modification 50%
• Cell Culture 50%
• Dimerization 50%
• Cell Proliferation 50%
• Protein Interaction 50%
• Kinase 50%
• Phosphotransferase 50%
• Protein Kinase A 50%
• HRAS 50%
• Homodimerization 50%

Pharmacology, Toxicology and Pharmaceutical Science

• Phosphotransferase 100%
• Neoplasm 100%
• Drug Development 100%
• Cyclic AMP Dependent Protein Kinase 100%