Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation

J. Richard Coast; Regina M. Romeo; Sharon S. Cassidy

doi:10.1016/0034-5687(89)90038-8

Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation

J. Richard Coast, Regina M. Romeo, Sharon S. Cassidy

Biological Sciences

Research output: Contribution to journal › Article › peer-review

2 Scopus citations

Abstract

This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.

Original language	English (US)
Pages (from-to)	279-288
Number of pages	10
Journal	Respiration Physiology
Volume	75
Issue number	3
DOIs	https://doi.org/10.1016/0034-5687(89)90038-8
State	Published - Mar 1989

Keywords

Capsaicin
Diaphragm
Dog
Pulmonary C-fiber

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(89)90038-8

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title = "Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation",

abstract = "This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.",

keywords = "Capsaicin, Diaphragm, Dog, Pulmonary C-fiber",

author = "Coast, {J. Richard} and Romeo, {Regina M.} and Cassidy, {Sharon S.}",

note = "Funding Information: Acknowledgements. This study was performed with financial support by the American Heart Association with funds contributed by the Texas Affiliate of the American Heart Association, during the tenure ofJ. R. Coast as a postdoctoral fellow supported by the National Heart, Lung, and Blood Institute Training Grant in Pulmonary Pathophysiology HL-07362.",

year = "1989",

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doi = "10.1016/0034-5687(89)90038-8",

language = "English (US)",

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AU - Romeo, Regina M.

AU - Cassidy, Sharon S.

N1 - Funding Information: Acknowledgements. This study was performed with financial support by the American Heart Association with funds contributed by the Texas Affiliate of the American Heart Association, during the tenure ofJ. R. Coast as a postdoctoral fellow supported by the National Heart, Lung, and Blood Institute Training Grant in Pulmonary Pathophysiology HL-07362.

PY - 1989/3

Y1 - 1989/3

N2 - This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.

AB - This study was performed to assess the effect of pulmonary C-fiber stimulation with capsaicin on vascular resistance in the diaphragm. Nine dogs were anesthetized with pentobarbital sodium and were instrumented with right and left ventricular catheters. The left phrenic artery was isolated and perfused from an extracorporeal reservoir. Right ventricular capsaicin injections (5-20 μg/kg) caused significant decreases in phrenic perfusion pressure (-16%), systemic arterial pressure (-32%), and heart rate (-19%). Injection of identical doses of capsaicin into the left ventricle led to no significant changes in phrenic arterial perfusion pressure or systemic arterial pressure but a 10% decrease in heart rate. Bilateral cervical vagotomy eliminated the responses to both right and left ventricular injection of capsaicin, as did administration of the autonomic ganglion blocker hexamethonium bromide. The results indicate that pulmonary C-fiber stimulation reflexly vasolidates vessels in the diaphragm.

KW - Capsaicin

KW - Diaphragm

KW - Dog

KW - Pulmonary C-fiber

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Diaphragmatic vasolidation elicited by pulmonary C-fiber stimulation

Abstract

Keywords

ASJC Scopus subject areas

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