Determinants of protein folding and aggregation in P22 tailspike protein

Matthew J. Gage, Brian G. Lefebvre, Anne S. Robinson

Research output: Chapter in Book/Report/Conference proceedingChapter


The P22 tailspike protein is a well-studied model system for understanding multimeric protein folding and aggregation. It is one of the few systems for which both in vivo and in vitro folding pathways have been well characterized. Aggregation of the P22 tailspike occurs through a multimeric addition pathway in which both monomeric and multimeric protein can associate with existing aggregates promoting aggregate growth.

Original languageEnglish (US)
Title of host publicationMisbehaving Proteins
Subtitle of host publicationProtein (Mis)Folding, Aggregation, and Stability
PublisherSpringer New York
Number of pages18
ISBN (Electronic)9780387360638
ISBN (Print)0387305084, 9780387305080
StatePublished - 2006

ASJC Scopus subject areas

  • General Biochemistry, Genetics and Molecular Biology


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