Abstract
The P22 tailspike protein is a well-studied model system for understanding multimeric protein folding and aggregation. It is one of the few systems for which both in vivo and in vitro folding pathways have been well characterized. Aggregation of the P22 tailspike occurs through a multimeric addition pathway in which both monomeric and multimeric protein can associate with existing aggregates promoting aggregate growth.
Original language | English (US) |
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Title of host publication | Misbehaving Proteins |
Subtitle of host publication | Protein (Mis)Folding, Aggregation, and Stability |
Publisher | Springer New York |
Pages | 247-264 |
Number of pages | 18 |
ISBN (Electronic) | 9780387360638 |
ISBN (Print) | 0387305084, 9780387305080 |
DOIs | |
State | Published - 2006 |
ASJC Scopus subject areas
- General Biochemistry, Genetics and Molecular Biology