@article{e5accaf79d324442b14b559a889b96e4,
title = "Detection of SARS-CoV-2 and its S and N proteins using surface enhanced Raman spectroscopy",
abstract = "The COVID-19 pandemic demonstrated the critical need for accurate and rapid testing for virus detection. This need has generated a high number of new testing methods aimed at replacing RT-PCR, which is the golden standard for testing. Most of the testing techniques are based on biochemistry methods and require chemicals that are often expensive and the supply might become scarce in a large crisis. In the present paper we suggest the use of methods based on physics that leverage novel nanomaterials. We demonstrate that using Surface Enhanced Raman Spectroscopy (SERS) of virion particles a very distinct spectroscopic signature of the SARS-CoV-2 virus can be obtained. We demonstrate that the spectra are mainly composed by signals from the spike (S) and nucleocapsid (N) proteins. It is believed that a clinical test using SERS can be developed. The test will be fast, inexpensive, and reliable. It is also clear that SERS can be used for analysis of structural changes on the S and N proteins. This will be an example of application of nanotechnology and properties of nanoparticles for health and social related matters.",
author = "Sanchez, {John Eder} and Jaramillo, {Sierra A.} and Erik Settles and {Velazquez Salazar}, {J. Jesus} and Alexander Lehr and Javier Gonzalez and {Rodr{\'i}guez Aranda}, Carmen and Navarro-Contreras, {Hugo R.} and Raniere, {Marlee O.} and Maxx Harvey and Wagner, {David M.} and Andrew Koppisch and Robert Kellar and Paul Keim and {Jose Yacaman}, Miguel",
note = "Funding Information: The authors would like to acknowledge the financial support from the NSF Rapid Grant # 2030488. We also acknowledge the NSF-NCI-SW center for financial support in using ASU cores and the MIRA-NAU Institute for grant on metallic nanoparticles. We acknowledge the access to Laboratorio Nacional de An{\'a}lisis F{\'i}sicos, Qu{\'i}micos y Biol{\'o}gicos-UASLP (LANAFQB), during the course of this research. This project benefited from the financial support granted by Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACyT) M{\'e}xico for Mantenimiento de Infraestructura Cient{\'i}fica en Laboratorios Nacionales 2020-314931, as well as from FAI-UASLP. Flinn Foundation and NAU TRIF funds were used to support the virus work. Funding Information: The authors would like to acknowledge the nancial support from the NSF Rapid Grant # 2030488. We also acknowledge the NSF-NCI-SW center for nancial support in using ASU cores and the MIRA-NAU Institute for grant on metallic nanoparticles. We acknowledge the access to Laboratorio Nacional de An{\'a}lisis F{\'i}sicos, Q{\'u}ımicos y Biol{\'o}gicos-UASLP (LANAFQB), during the course of this research. This project beneted from the nancial support granted by Consejo Nacional de Ciencia y Tecnolog{\'i}a (CONACyT) M{\'e}xico for Mantenimiento de Infraestructura Cient{\'i}ca en Laboratorios Nacionales 2020-314931, as well as from FAI-UASLP. Flinn Foundation and NAU TRIF funds were used to support the virus work. Publisher Copyright: {\textcopyright} The Royal Society of Chemistry 2021.",
year = "2021",
month = jul,
day = "2",
doi = "10.1039/d1ra03481b",
language = "English (US)",
volume = "11",
pages = "25788--25794",
journal = "RSC Advances",
issn = "2046-2069",
publisher = "Royal Society of Chemistry",
number = "41",
}