Design of the mammalian respiratory system. VIII. Capillaries in skeletal muscles

Hans Hoppeler; Odile Mathieu; Ewald R. Weibel; Rudolf Krauer; Stan L. Lindstedt; C. R. Taylor

doi:10.1016/0034-5687(81)90080-3

Design of the mammalian respiratory system. VIII. Capillaries in skeletal muscles

Hans Hoppeler, Odile Mathieu, Ewald R. Weibel, Rudolf Krauer, Stan L. Lindstedt, C. R. Taylor

Biological Sciences

Research output: Contribution to journal › Article › peer-review

102 Scopus citations

Abstract

The relationship between capillary density and mitochondrial volume density in skeletal muscle tissue is investigated on 25 African mammals ranging in body mass from 0.4 to 251 kg. As a general trend higher capillary densities, N_A(c,f), are found in muscles with higher volume densities of mitochondria, V_V(mt,f). The individual data however show considerable scatter. Part of this scatter can be explained by the fact that N_A(c,f) alone is not a sufficient parameter to account for functional properties of the vascular supply. The regional variability of the capillary network from arterial to venous end also contributes to the data spread. A number of physiological variables of the vascular compartment may also influence the relationship of capillary counts to the mitochondrial densities of muscle fibers. This relationship therefore cannot be expected to be a simple one.

Original language	English (US)
Pages (from-to)	129-150
Number of pages	22
Journal	Respiration Physiology
Volume	44
Issue number	1
DOIs	https://doi.org/10.1016/0034-5687(81)90080-3
State	Published - Apr 1981

Keywords

African mammals
Allometry
Capillary density
Capillary length
Mitochondrial density
Muscle fiber types

ASJC Scopus subject areas

Physiology
Pulmonary and Respiratory Medicine

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10.1016/0034-5687(81)90080-3

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title = "Design of the mammalian respiratory system. VIII. Capillaries in skeletal muscles",

abstract = "The relationship between capillary density and mitochondrial volume density in skeletal muscle tissue is investigated on 25 African mammals ranging in body mass from 0.4 to 251 kg. As a general trend higher capillary densities, NA(c,f), are found in muscles with higher volume densities of mitochondria, VV(mt,f). The individual data however show considerable scatter. Part of this scatter can be explained by the fact that NA(c,f) alone is not a sufficient parameter to account for functional properties of the vascular supply. The regional variability of the capillary network from arterial to venous end also contributes to the data spread. A number of physiological variables of the vascular compartment may also influence the relationship of capillary counts to the mitochondrial densities of muscle fibers. This relationship therefore cannot be expected to be a simple one.",

keywords = "African mammals, Allometry, Capillary density, Capillary length, Mitochondrial density, Muscle fiber types",

author = "Hans Hoppeler and Odile Mathieu and Weibel, {Ewald R.} and Rudolf Krauer and Lindstedt, {Stan L.} and Taylor, {C. R.}",

note = "Funding Information: * This work was supported by grants from the Swiss National Science Foundation (3.394.74 and 3.332.78) and from the Sandoz Foundation. i Present address : Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, U.S.A. 129",

year = "1981",

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doi = "10.1016/0034-5687(81)90080-3",

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AU - Hoppeler, Hans

AU - Mathieu, Odile

AU - Weibel, Ewald R.

AU - Krauer, Rudolf

AU - Lindstedt, Stan L.

AU - Taylor, C. R.

N1 - Funding Information: * This work was supported by grants from the Swiss National Science Foundation (3.394.74 and 3.332.78) and from the Sandoz Foundation. i Present address : Museum of Comparative Zoology, Harvard University, Cambridge, MA 02138, U.S.A. 129

PY - 1981/4

Y1 - 1981/4

N2 - The relationship between capillary density and mitochondrial volume density in skeletal muscle tissue is investigated on 25 African mammals ranging in body mass from 0.4 to 251 kg. As a general trend higher capillary densities, NA(c,f), are found in muscles with higher volume densities of mitochondria, VV(mt,f). The individual data however show considerable scatter. Part of this scatter can be explained by the fact that NA(c,f) alone is not a sufficient parameter to account for functional properties of the vascular supply. The regional variability of the capillary network from arterial to venous end also contributes to the data spread. A number of physiological variables of the vascular compartment may also influence the relationship of capillary counts to the mitochondrial densities of muscle fibers. This relationship therefore cannot be expected to be a simple one.

AB - The relationship between capillary density and mitochondrial volume density in skeletal muscle tissue is investigated on 25 African mammals ranging in body mass from 0.4 to 251 kg. As a general trend higher capillary densities, NA(c,f), are found in muscles with higher volume densities of mitochondria, VV(mt,f). The individual data however show considerable scatter. Part of this scatter can be explained by the fact that NA(c,f) alone is not a sufficient parameter to account for functional properties of the vascular supply. The regional variability of the capillary network from arterial to venous end also contributes to the data spread. A number of physiological variables of the vascular compartment may also influence the relationship of capillary counts to the mitochondrial densities of muscle fibers. This relationship therefore cannot be expected to be a simple one.

KW - African mammals

KW - Allometry

KW - Capillary density

KW - Capillary length

KW - Mitochondrial density

KW - Muscle fiber types

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Design of the mammalian respiratory system. VIII. Capillaries in skeletal muscles

Abstract

Keywords

ASJC Scopus subject areas

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