While building simulation software tools are excellent at carrying out accurate and realistic building simulations they only provide very basic control methods. On the other hand, control engineers and researchers have explored advanced control strategies for energy-efficient operation of a building, but more often than not, such methods are based on simplified physical models instead. We present MLE+, a tool for energy-efficient building automation design, co-simulation and analysis. The tool leverages the high-fidelity plant simulation capabilities of building modeling software, EnergyPlus, and the scientific computation and design capabilities of Matlab/Simulink for controller design. MLE+ facilitates integrated building simulation and controller formulation with integrated support for system identification, control design, optimization, simulation analysis and communication between software applications and building equipment. In this demo, we will show how MLE+ can be used for systematic design of controllers for energy-efficient building model in EnergyPlus. We will also show the capability of MLE+ to control Heating Ventilation and Air Conditioning (HVAC) devices in buildings through the BACnet protocol.