CRISPR-Cas9-Mutated Pregnane X Receptor (pxr) Retains Pregnenolone-induced Expression of cyp3a65 in Zebrafish (Danio rerio) Larvae

Keyphrases

• Zebrafish (Danio rerio) Embryo 100%
• Induced Expression 100%
• Cas9 Protein 100%
• Pregnenolone 100%
• Pregnane X Receptor 100%
• Cyp3a65 100%
• Zebrafish 57%
• Compensatory Mechanisms 28%
• Cytochrome P450 3A (CYP3A) 28%
• Gene mutation 14%
• Transcriptional Response 14%
• Ligand-binding Domain 14%
• Mutant Alleles 14%
• Coding Region 14%
• Vertebrate Species 14%
• Deleterious Effects 14%
• MRNA Expression 14%
• Functional Studies 14%
• Across Species 14%
• DNA Binding 14%
• Functional Genes 14%
• Loss Function 14%
• Drug Response 14%
• Drug Exposure 14%
• Gene Products 14%
• Knock-out Studies 14%
• Reporter Gene 14%
• Expression Gene 14%
• Morpholino Knockdown 14%
• Gene Activity 14%
• Xenobiotic Exposure 14%
• Transcriptional Effects 14%
• NR1I2 14%
• Nuclear Receptor 14%
• Chemical Defensome 14%
• Ligand-independent Activation 14%

Biochemistry, Genetics and Molecular Biology

• Zebra Fish 100%
• CRISPR/Cas9 100%
• Pregnenolone 100%
• Pregnane X Receptor 100%
• Allele 28%
• CYP3A 28%
• Gene Mutation 14%
• Messenger RNA 14%
• Coding Region 14%
• Transcription 14%
• Morpholino 14%
• DNA Binding 14%
• Gene Product 14%
• Reporter Gene 14%
• Gene Activity 14%
• Nuclear Receptor 14%
• Ligand Binding Domain 14%

Neuroscience

• CRISPR 100%
• Pregnane X Receptor 100%
• Pregnenolone 100%
• Cytochrome P450 3A 28%
• Ligand Binding 14%
• Gene Mutation 14%
• DNA Binding 14%
• Reporter Gene 14%
• Gene Product 14%
• Morpholino 14%
• Gene Activity 14%
• Coding Region 14%
• Nuclear Receptor 14%