Copper induced cyclization of α,β-unsaturated carbonyl compounds to isoxazoles

Cindy C. Browder, Christopher B. Moss, Matthew B. Kraft, Paige L. Petrucka, Tara S. Morey, Christopher W. Leach, Nicholas C. Gearhart

Research output: Contribution to journalArticlepeer-review


An unusual synthesis of isoxazoles from α,β-unsaturated ketoximes is reported. Using very inexpensive reagents, isoxazoles are isolated in good yields. Notably, a mixture of E and Z oxime isomers is employed. Initial studies indicate the oxidative cyclization reaction does not proceed via radical route; a copper insertion/elimation route is proposed.

Original languageEnglish (US)
Pages (from-to)229-233
Number of pages5
JournalLetters in Organic Chemistry
Issue number4
StatePublished - May 2011


  • Copper-mediated
  • Cyclization
  • Isoxazole

ASJC Scopus subject areas

  • Biochemistry
  • Organic Chemistry


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