An unusual synthesis of isoxazoles from α,β-unsaturated ketoximes is reported. Using very inexpensive reagents, isoxazoles are isolated in good yields. Notably, a mixture of E and Z oxime isomers is employed. Initial studies indicate the oxidative cyclization reaction does not proceed via radical route; a copper insertion/elimation route is proposed.
|Original language||English (US)|
|Number of pages||5|
|Journal||Letters in Organic Chemistry|
|State||Published - May 1 2011|
ASJC Scopus subject areas
- Organic Chemistry