Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species

Nawarat Somprasong; Jinhee Yi; Carina M. Hall; Jessica R. Webb; Jason W. Sahl; David M. Wagner; Paul Keim; Bart J. Currie; Herbert P. Schweizer

doi:10.1128/AAC.00920-21

Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species

Nawarat Somprasong, Jinhee Yi, Carina M. Hall, Jessica R. Webb, Jason W. Sahl, David M. Wagner, Paul Keim, Bart J. Currie, Herbert P. Schweizer

Biological Sciences

Research output: Contribution to journal › Article › peer-review

8 Scopus citations

Abstract

Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.

Original language	English (US)
Article number	e00920-21
Journal	Antimicrobial Agents and Chemotherapy
Volume	65
Issue number	9
DOIs	https://doi.org/10.1128/AAC.00920-21
State	Published - Sep 2021

Keywords

Burkholderia
Multidrug resistance
RND efflux pumps

ASJC Scopus subject areas

Pharmacology
Pharmacology (medical)
Infectious Diseases

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10.1128/AAC.00920-21

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Somprasong, N., Yi, J., Hall, C. M., Webb, J. R., Sahl, J. W., Wagner, D. M., Keim, P., Currie, B. J., & Schweizer, H. P. (2021). Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species. Antimicrobial Agents and Chemotherapy, 65(9), Article e00920-21. https://doi.org/10.1128/AAC.00920-21

Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species. / Somprasong, Nawarat; Yi, Jinhee; Hall, Carina M. et al.
In: Antimicrobial Agents and Chemotherapy, Vol. 65, No. 9, e00920-21, 09.2021.

Research output: Contribution to journal › Article › peer-review

Somprasong, N, Yi, J, Hall, CM, Webb, JR, Sahl, JW, Wagner, DM, Keim, P, Currie, BJ & Schweizer, HP 2021, 'Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species', Antimicrobial Agents and Chemotherapy, vol. 65, no. 9, e00920-21. https://doi.org/10.1128/AAC.00920-21

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abstract = "Burkholderia cepacia complex (Bcc) and Burkholderia pseudomallei complex (Bpc) species include pathogens that are typically multidrug resistant. Dominant intrinsic and acquired multidrug resistance mechanisms are efflux mediated by pumps of the resistance-nodulation-cell division (RND) family. From comparative bioinformatic and, in many instances, functional studies, we infer that RND pump-based resistance mechanisms are conserved in Burkholderia. We propose to use these findings as a foundation for adoption of a uniform RND efflux pump nomenclature.",

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AU - Keim, Paul

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Conservation of resistance-nodulation-cell division efflux pump-mediated antibiotic resistance in burkholderia cepacia complex and burkholderia pseudomallei complex species

Abstract

Keywords

ASJC Scopus subject areas

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