Compositionally and functionally distinct sinus microbiota in chronic rhinosinusitis patients have immunological and clinically divergent consequences

Keyphrases

• Microbiota 100%
• Chronic Rhinosinusitis 100%
• Sinus 100%
• Coriobacteriaceae 42%
• Bacterial Microbiota 28%
• Host Immune Response 28%
• Permutational multivariate Analysis of Variance (PERMANOVA) 28%
• Immune Response 14%
• Streptococcaceae 14%
• Pseudomonadaceae 14%
• Healthy Individuals 14%
• Increased Incidence 14%
• Pathogenic Bacteria 14%
• Fisher 14%
• 16S rRNA Gene Sequencing 14%
• Co-colonization 14%
• Specific Pattern 14%
• Relative Risk 14%
• Patient Demographics 14%
• Mucosal Immune Response 14%
• Sinonasal Inflammation 14%
• Nasal Polyps 14%
• Kruskal-Wallis Test 14%
• Gene Pathway 14%
• Sinus Microbiome 14%
• Heterogeneous Disease 14%
• Patient Clustering 14%
• Interleukin-5 (IL-5) 14%
• Response Features 14%
• PPAR Signaling Pathway 14%
• Patient Heterogeneity 14%
• Tryptophan Metabolism 14%
• Pathogenic Microbiota 14%
• Staphylococcaceae 14%
• Ansamycins 14%
• Metagenomic Profiling 14%
• Endoscopic Sinus Surgery 14%
• Microbial Dysbiosis 14%
• RNA Profiling 14%
• Clinical Phenotype 14%
• Tailored Therapy 14%

Immunology and Microbiology

• Microflora 100%
• Corynebacteriaceae 100%
• Bacterial Flora 66%
• Host Immune Response 66%
• Immune Response 33%
• Signal Transduction 33%
• Gene Sequence 33%
• Metagenomics 33%
• Microbiome 33%
• Pseudomonadaceae 33%
• Streptococcaceae 33%
• Mucosal Immune Response 33%
• Staphylococcaceae 33%
• Tryptophan Metabolism 33%