Abstract
Comparison of the whole-genome sequence of Bacillus anthracis isolated from a victim of a recent bioterrorist anthrax attack with a reference reveals 60 new markers that include single nucleotide polymorphisms (SNPs), inserted or deleted sequences, and tandem repeats. Genome comparison detected four high-quality SNPs between the two sequenced B. anthracis chromosomes and seven differences among different preparations of the reference genome. These markers have been tested on a collection of anthrax isolates and were found to divide these samples into distinct families. These results demonstrate that genome-based analysis of microbial pathogens will provide a powerful new tool for investigation of infectious disease outbreaks.
Original language | English (US) |
---|---|
Pages (from-to) | 2028-2033 |
Number of pages | 6 |
Journal | Science |
Volume | 296 |
Issue number | 5575 |
DOIs | |
State | Published - Jun 14 2002 |
ASJC Scopus subject areas
- General