Comparative Embryology of the Carotid Body

Steven C. Hempleman, Stephen J. Warburton

Research output: Contribution to journalReview articlepeer-review

22 Scopus citations


Vertebrate carotid bodies and related structures (branchial arch oxygen chemoreceptors in fishes, carotid labyrinth in amphibians, chemoreceptors in the wall of the common carotid and its branches in birds) develop in embryos when neural crest cells, blood vessels, and nerve fibers from sympathetic and cranial nerve ganglia invade mesenchymal primordia in the wall of the 3rd branchial arch. This review focuses on literature published since the 1970's investigating similarities and differences in the embryological development of 3rd arch oxygen chemoreceptors, especially between mammals and birds, but also considering reptiles, amphibians and fishes.

Original languageEnglish (US)
Pages (from-to)3-8
Number of pages6
JournalRespiratory Physiology and Neurobiology
Issue number1
StatePublished - Jan 1 2013


  • branchial arch
  • carotid body
  • neural crest

ASJC Scopus subject areas

  • General Neuroscience
  • Physiology
  • Pulmonary and Respiratory Medicine


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