Clonal heterogeneity of lymphoid malignancies correlates with poor prognosis

Miyuki Suguro, Noriaki Yoshida, Akira Umino, Harumi Kato, Hiroyuki Tagawa, Masao Nakagawa, Noriko Fukuhara, Sivasundaram Karnan, Ichiro Takeuchi, Toby D. Hocking, Kotaro Arita, Kennosuke Karube, Shinobu Tsuzuki, Shigeo Nakamura, Tomohiro Kinoshita, Masao Seto

Research output: Contribution to journalArticlepeer-review

15 Scopus citations


Clonal heterogeneity in lymphoid malignancies has been recently reported in adult T-cell lymphoma/leukemia, peripheral T-cell lymphoma, not otherwise specified, and mantle cell lymphoma. Our analysis was extended to other types of lymphoma including marginal zone lymphoma, follicular lymphoma and diffuse large B-cell lymphoma. To determine the presence of clonal heterogeneity, 332 cases were examined using array comparative genomic hybridization analysis. Results showed that incidence of clonal heterogeneity varied from 25% to 69% among different types of lymphoma. Survival analysis revealed that mantle cell lymphoma and diffuse large B-cell lymphoma with clonal heterogeneity showed significantly poorer prognosis, and that clonal heterogeneity was confirmed as an independent predictor of poor prognosis for both types of lymphoma. Interestingly, 8q24.1 (MYC) gain, 9p21.3 (CDKN2A/2B) loss and 17p13 (TP53, ATP1B2, SAT2, SHBG) loss were recurrent genomic lesions among various types of lymphoma with clonal heterogeneity, suggesting at least in part that alterations of these genes may play a role in clonal heterogeneity. In this issue of Cancer Science, Suguro et al. have developed a method for the assessment of clonal heterogeneity base on array CGH analysis. 332 cases comprising six types of lymphoma were investigated the presence of clonal heterogeneity. Cases with clonal heterogeneity showed poor prognosis and recurrent genomic copy number alterations of MYC, CDKN2A/2B, and TP53 irrespective lymphoma type.

Original languageEnglish (US)
Pages (from-to)897-904
Number of pages8
JournalCancer Science
Issue number7
StatePublished - Jul 2014
Externally publishedYes


  • Array comparative genomic hybridization
  • Heterogeneity
  • Malignant lymphoma
  • Patient outcome assessment
  • Tumor cell population

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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