Clinical outcomes from blended care therapy for anxiety and depression in the year after treatment

Jennifer L. Lee, Shih Yin Chen, Robert E. Wickham, Pam Wang, Monica S. Wu, Alethea A. Varra, Connie E. Chen, Anita Lungu

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Scalable evidence-based treatments for anxiety and depression, such as blended care therapy (BCT) that integrate digital tools are effective, but reporting on long-term outcomes is limited. Method: This pragmatic observational study examined the symptom stability and trajectories of individuals in the year following engagement in a BCT program. Participants included adults with clinical anxiety and/or depression measured by the Generalized Anxiety Disorder-7 (GAD-7) or Patient Health Questionnaire-9 (PHQ-9). Assessments were sent during the initial episode of care and in the year following. Results: Participants included 27,835 adults (depression: 17,686 and anxiety: 24,853). Of these, 11,465 (41 % of those who received initial care; depression: 7223; anxiety: 10,218) completed at least one follow-up assessment (FUA). Average age was 34 years, 68–69 % were female, and 48–49 % were White across subsamples. Among FUA respondents, rates of reliable improvement or recovery on the PHQ-9 or GAD-7 for those who did not receive additional therapy were above 81 % across follow-up periods. Growth curve analysis for those who did not return for additional therapy revealed that both depression and anxiety groups demonstrated a statistically significant yet small linear effect of time in the year following treatment, with a 1.6–2.1 point increase in scores over the 12-month period. Conclusions: Among clients who completed FUAs and received no additional therapy, reliable improvement and recovery rates were high. Growth curve analysis demonstrated a small increase in symptoms over the 12-month interval, providing pragmatic evidence of long-term stability of treatment gains from BCT for anxiety and depression in a real-world setting.

Original languageEnglish (US)
Article number100798
JournalInternet Interventions
Volume39
DOIs
StatePublished - Mar 2025

Keywords

  • 12-month follow-up
  • Anxiety
  • Blended care therapy
  • Depression
  • Longitudinal outcomes
  • Mental health

ASJC Scopus subject areas

  • Health Informatics

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