Clinical features and genetic background of the sympatric species Paracoccidioides brasiliensis and Paracoccidioides americana

Priscila Marques De Macedo, Marcus De Melo Teixeira, Bridget M. Barker, Rosely Maria Zancopé-Oliveira, Rodrigo Almeida-Paes, Antonio Carlos Francesconi Do Valle

Research output: Contribution to journalArticlepeer-review

21 Scopus citations

Abstract

Introduction The agents of paracoccidioidomycosis, historically identified as Paracoccidioides brasiliensis, are in fact different phylogenetic species. This study aims to evaluate associations between Paracoccidioides phylogenetic species and corresponding clinical data. Methods Paracoccidioides strains from INI/Fiocruz patients (1998-2016) were recovered. Sociodemographic, epidemiological, clinical, serological, therapeutic and prognostic data of the patients were collected to evaluate possible associations of these variables with the fungal species identified through partial sequencing of the ADP-ribosylation factor (arf) and the 43-kDa-glycoprotein (gp43) genes. Results Fifty-four fungal strains were recovered from 47 patients, most (72.3%) infected in Rio de Janeiro state, Brazil. Forty-one cases were caused by Paracoccidioides brasiliensis and six by Paracoccidioides americana (former PS2). P. brasiliensis was responsible for severe lymph abdominal forms, whereas patients infected with P. americana presented a high rate of adrenal involvement. However, no statistically significant associations were found for all variables studied. P. americana presented 100% reactivity to immunodiffusion, even when tested against antigens from other species, while negative results were observed in 9 (20%) cases caused by P. brasiliensis, despite being tested against a homologous antigen. Conclusions P. brasiliensis and P. americana are sympatric and share similar clinical features and habitat, where they may compete for similar hosts.

Original languageEnglish (US)
Article numbere0007309
JournalPLoS neglected tropical diseases
Volume13
Issue number4
DOIs
StatePublished - 2019

ASJC Scopus subject areas

  • Public Health, Environmental and Occupational Health
  • Infectious Diseases

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