Carbon-starvation induction of the ugp operon, encoding the binding protein-dependent sn-glycerol-3-phosphate transport system in Escherichia coli

Ti Zhi Su, Herbert P. Schweizer, Dale L. Oxender

Research output: Contribution to journalArticlepeer-review

13 Scopus citations

Abstract

The gene products of the ugp operon of Escherichia coli are responsible for the uptake of sn-glycerol-3-phosphate and certain glycerophosphodiesters. The regulation of ugp is mainly phoBR-dependent. Significant expression, however, can be observed even in the presence of high concentrations of phosphate, a condition which normally completely represses pho expression. Pho-independent ugp expression was found to be derepressed during the late logarithmic growth phase due to carbon starvation. Among different carbon sources tested, glucose caused the most complete repression. Addition of cAMP prevented glucose repression, indicating that a cAMP-CRP control mechanism may be directly or indirectly involved in the carbon-starvation response. This conclusion is supported by the fact that pho-independent ugp expression correlated with the presence of the cya and crp gene products.

Original languageEnglish (US)
Pages (from-to)28-32
Number of pages5
JournalMGG Molecular & General Genetics
Volume230
Issue number1-2
DOIs
StatePublished - Nov 1991
Externally publishedYes

Keywords

  • Regulation
  • ugp operon, gene regulation

ASJC Scopus subject areas

  • Genetics

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