Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

Lourdes Garza-Ocañas, Domingo A. Ferrer, Justin Burt, Luis A. Diaz-Torres, Mónica Ramírez Cabrera, Victor Tamez Rodríguez, Rubén Luján Rangel, Dwight Romanovicz, Miguel Jose-Yacaman

Research output: Contribution to journalArticlepeer-review

77 Scopus citations

Abstract

Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.

Original languageEnglish (US)
Pages (from-to)204-210
Number of pages7
JournalMetallomics
Volume2
Issue number3
DOIs
StatePublished - 2010
Externally publishedYes

ASJC Scopus subject areas

  • Chemistry (miscellaneous)
  • Biophysics
  • Biochemistry
  • Biomaterials
  • Metals and Alloys

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