Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

Lourdes Garza-Ocañas; Domingo A. Ferrer; Justin Burt; Luis A. Diaz-Torres; Mónica Ramírez Cabrera; Victor Tamez Rodríguez; Rubén Luján Rangel; Dwight Romanovicz; Miguel Jose-Yacaman

doi:10.1039/b916107d

Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

Lourdes Garza-Ocañas, Domingo A. Ferrer, Justin Burt, Luis A. Diaz-Torres, Mónica Ramírez Cabrera, Victor Tamez Rodríguez, Rubén Luján Rangel, Dwight Romanovicz, Miguel Jose-Yacaman

Research output: Contribution to journal › Article › peer-review

81 Scopus citations

Abstract

Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag⁺ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.

Original language	English (US)
Pages (from-to)	204-210
Number of pages	7
Journal	Metallomics
Volume	2
Issue number	3
DOIs	https://doi.org/10.1039/b916107d
State	Published - 2010
Externally published	Yes

ASJC Scopus subject areas

General Medicine

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title = "Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats",

abstract = "Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.",

author = "Lourdes Garza-Oca{\~n}as and Ferrer, {Domingo A.} and Justin Burt and Diaz-Torres, {Luis A.} and Cabrera, {M{\'o}nica Ram{\'i}rez} and Rodr{\'i}guez, {Victor Tamez} and Rangel, {Rub{\'e}n Luj{\'a}n} and Dwight Romanovicz and Miguel Jose-Yacaman",

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doi = "10.1039/b916107d",

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AU - Garza-Ocañas, Lourdes

AU - Ferrer, Domingo A.

AU - Burt, Justin

AU - Diaz-Torres, Luis A.

AU - Cabrera, Mónica Ramírez

AU - Rodríguez, Victor Tamez

AU - Rangel, Rubén Luján

AU - Romanovicz, Dwight

AU - Jose-Yacaman, Miguel

PY - 2010

Y1 - 2010

N2 - Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.

AB - Silver nanocrystals (Ag NCs) hold promising antibiotic and antiviral properties in biological systems. The biodistribution of silver nanostructures injected into animals in vivo is currently unknown, remaining as a fundamental issue for potential therapeutic applications. Here, we injected Ag NCs capped with bovine serum albumin (BSA) in live rats to elucidate their fate in several organs including liver, heart and brain. Very significant accumulations of nanoparticles were confirmed by inductively coupled plasma mass spectroscopy (ICPMS) and transmission electron microscopy (TEM) techniques on the liver and heart. In contrast, the brain tissue did not reveal evidence of particles content. Our results suggest that Ag+ permeated across the blood-brain barrier (BBB), and followed swift clearance from the organ.

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Biodistribution and long-term fate of silver nanoparticles functionalized with bovine serum albumin in rats

Abstract

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