Biodirected synthesis and nanostructural characterization of anisotropic gold nanoparticles

Germán Plascencia-Villa, Daniel Torrente, Marcelo Marucho, Miguel José-Yacamán

Research output: Contribution to journalArticlepeer-review

20 Scopus citations

Abstract

Gold nanoparticles with anisotropic structures have tunable absorption properties and diverse bioapplications as image contrast agents, plasmonics, and therapeutic-diagnostic materials. Amino acids with electrostatically charged side chains possess inner affinity for metal ions. Lysine (Lys) efficiently controlled the growing into star-shape nanoparticles with controlled narrow sizes (30-100 nm) and produced in high yields (85-95%). Anisotropic nanostructures showed tunable absorbance from UV to NIR range, with extraordinary colloidal stability (-26 to-42 mV) and surface-enhanced Raman scattering properties. Advanced electron microscopy characterization through ultra-high-resolution SEM, STEM, and HR-TEM confirmed the size, nanostructure, crystalline structure, and chemical composition. Molecular dynamics simulations revealed that Lys interacted preferentially with Au(I) through the-COOH group instead of their positive side chains with a binding free energy (BFE) of 3.4 kcal mol-1. These highly monodisperse and colloidal stable anisotropic particles prepared with biocompatible compounds may be employed in biomedical applications.

Original languageEnglish (US)
Pages (from-to)3527-3536
Number of pages10
JournalLangmuir
Volume31
Issue number11
DOIs
StatePublished - Mar 24 2015
Externally publishedYes

ASJC Scopus subject areas

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

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