Audiologic threshold monitoring of patients receiving ototoxic drugs: Preliminary report

William L. Meyerhoff, Wende Yellin, Gerhard E. Maale, Peter S. Roland

Research output: Contribution to journalArticlepeer-review

14 Scopus citations


An effort was made to determine the efficacy of auditory threshold monitoring of patients receiving ototoxic drugs. Forty-four patients treated with either tobramycin or vancomycin for osteomyelitis were tested at the beginning of treatment, following treatment, and twice weekly during treatment when possible. All patients had renal function carefully monitored. Peak and trough drug levels were kept out of the toxic range throughout the study. In no patient did indisputable ototoxicity occur, and therefore, no conclusion about the most efficacious schedule for auditory monitoring of patients receiving ototoxic drugs was made, and what constitutes a significant intratherapeutic threshold shift is still in question. Until further data are collected, monitoring of renal function and peak and trough drug levels, as well as patient counseling, is recommended. Pretherapy and posttherapy auditory monitoring and intratherapeutic monitoring of high-risk patients and those who develop aural symptoms may prove beneficial.

Original languageEnglish (US)
Pages (from-to)950-954
Number of pages5
JournalAnnals of Otology, Rhinology & Laryngology
Issue number12
StatePublished - Dec 1989


  • ototoxicity
  • peak and trough levels
  • renal function

ASJC Scopus subject areas

  • Otorhinolaryngology


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