TY - JOUR
T1 - Associations between serum polybrominated diphenyl ethers and thyroid hormones in a cross sectional study of a remote Alaska Native population
AU - Byrne, Samuel C.
AU - Miller, Pamela
AU - Seguinot-Medina, Samarys
AU - Waghiyi, Vi
AU - Buck, C. Loren
AU - Von Hippel, Frank A.
AU - Carpenter, David O.
N1 - Funding Information:
The authors would like to thank the many individuals who contributed to accomplishing this research including Jane Kava, Jesse Gologergen, Erika Apatiki, Kristi Apangalook, Tiffany Immingan, Millie Kingeekuk, Susie Booshu, Sharon Campbell-Aningayou, Naomi Madsen, Shelley Klein-Apatiki, Carolyn Kava, Carol Gologergen, Bobby Ungwiluk, Kevin Zweifel, and Heidi Zimmer. The authors also thank Dr. Erin Bell, Dr. Michael Bloom, Dr. Kurunthachalam Kannan, and Dr. Lawrence Schell at the University at Albany for their comments on the manuscript. This study was supported by the National Institute of Environmental Health Sciences (NIH R01ES019620 and 2RO1ES019620).
Publisher Copyright:
© 2018 The Author(s).
PY - 2018/12/1
Y1 - 2018/12/1
N2 - Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants. Arctic indigenous peoples are exposed to PBDEs through a traditional diet high in marine mammals. PBDEs disrupt thyroid homeostasis. The aim of this study was to assess the relationship between serum PBDEs and thyroid function in a remote population of St. Lawrence Island Yupik. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska and measured for concentrations of PBDEs, free and total thyroxine (T4), free and total triiodothyronine (T3), and thyroid stimulating hormone (TSH). The relationships between PBDEs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations. Both BDE-47 and 153 remained significantly associated with thyroid hormones when BDE-47, BDE-153, and BDE-209 were covariates in the same model. There were no significant relationships between serum concentrations of PBDEs and either free or total T4. Individual PBDEs are associated with thyroid hormones in serum from a remote population of Alaska Natives, and directions of effect differ by congener.
AB - Polybrominated diphenyl ethers (PBDEs) are ubiquitous environmental pollutants. Arctic indigenous peoples are exposed to PBDEs through a traditional diet high in marine mammals. PBDEs disrupt thyroid homeostasis. The aim of this study was to assess the relationship between serum PBDEs and thyroid function in a remote population of St. Lawrence Island Yupik. Serum samples were collected from 85 individuals from St. Lawrence Island, Alaska and measured for concentrations of PBDEs, free and total thyroxine (T4), free and total triiodothyronine (T3), and thyroid stimulating hormone (TSH). The relationships between PBDEs and thyroid hormones were assessed using multiple linear regression fit with generalized estimating equations. Serum concentrations of several Penta-BDE congeners (BDE-28/33, 47, and 100) were positively associated with concentrations of TSH and free T3, while serum concentration of BDE-153 was negatively associated with total T3 concentrations. Both BDE-47 and 153 remained significantly associated with thyroid hormones when BDE-47, BDE-153, and BDE-209 were covariates in the same model. There were no significant relationships between serum concentrations of PBDEs and either free or total T4. Individual PBDEs are associated with thyroid hormones in serum from a remote population of Alaska Natives, and directions of effect differ by congener.
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U2 - 10.1038/s41598-018-20443-9
DO - 10.1038/s41598-018-20443-9
M3 - Article
C2 - 29396447
AN - SCOPUS:85041830234
SN - 2045-2322
VL - 8
JO - Scientific Reports
JF - Scientific Reports
IS - 1
M1 - 2198
ER -