TY - JOUR
T1 - Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians
AU - Bhatt, Ishan Sunilkuma
AU - Dias, Raquel
AU - Washnik, Nilesh
AU - Wang, Jin
AU - Guthrie, O'Neil
AU - Skelton, Michael
AU - Lane, Jeffery
AU - Wilder, Jason
N1 - Funding Information:
The original research work described by Phillips et al. (22) was supported by the National Institute on Deafness and Other Communication Disorders Grant R21DC009296-01. The research reported in this publication was partially supported by the National Cancer Institute of the National Institutes of Health under the award for the Partnership of Native American Cancer Prevention U54CA143925, and by the National Institute on Deafness and Other Communication Disorders Grant R21DC016704-01A1.
Publisher Copyright:
© 2020 Lippincott Williams and Wilkins. All rights reserved.
PY - 2020/6/1
Y1 - 2020/6/1
N2 - Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.
AB - Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.
KW - Catalase
KW - Estrogen-related receptor beta
KW - Gene association
KW - Music exposure
KW - Myosin heavy chain 14
KW - Noise-induced hearing loss
KW - Noise-induced hearing loss phenotype
KW - Nuclear receptor
KW - Potassium voltage-gated channel subfamily E regulatory subunit 1
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U2 - 10.1097/MAO.0000000000002615
DO - 10.1097/MAO.0000000000002615
M3 - Article
C2 - 32176153
AN - SCOPUS:85084695678
SN - 1531-7129
VL - 41
SP - e538-e547
JO - American Journal of Otology
JF - American Journal of Otology
IS - 5
ER -