Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

Ishan Sunilkuma Bhatt; Raquel Dias; Nilesh Washnik; Jin Wang; O'Neil Guthrie; Michael Skelton; Jeffery Lane; Jason Wilder

doi:10.1097/MAO.0000000000002615

Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

Ishan Sunilkuma Bhatt, Raquel Dias, Nilesh Washnik, Jin Wang, O'Neil Guthrie, Michael Skelton, Jeffery Lane, Jason Wilder

Research output: Contribution to journal › Article › peer-review

7 Scopus citations

Abstract

Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.

Original language	English (US)
Pages (from-to)	e538-e547
Journal	Otology and Neurotology
Volume	41
Issue number	5
DOIs	https://doi.org/10.1097/MAO.0000000000002615
State	Published - Jun 1 2020

Keywords

Catalase
Estrogen-related receptor beta
Gene association
Music exposure
Myosin heavy chain 14
Noise-induced hearing loss
Noise-induced hearing loss phenotype
Nuclear receptor
Potassium voltage-gated channel subfamily E regulatory subunit 1

ASJC Scopus subject areas

Otorhinolaryngology
Sensory Systems
Clinical Neurology

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10.1097/MAO.0000000000002615

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@article{2052dd34a4414838b9554b19a93b655d,

title = "Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians",

abstract = "Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.",

keywords = "Catalase, Estrogen-related receptor beta, Gene association, Music exposure, Myosin heavy chain 14, Noise-induced hearing loss, Noise-induced hearing loss phenotype, Nuclear receptor, Potassium voltage-gated channel subfamily E regulatory subunit 1",

author = "Bhatt, {Ishan Sunilkuma} and Raquel Dias and Nilesh Washnik and Jin Wang and O'Neil Guthrie and Michael Skelton and Jeffery Lane and Jason Wilder",

note = "Funding Information: The original research work described by Phillips et al. (22) was supported by the National Institute on Deafness and Other Communication Disorders Grant R21DC009296-01. The research reported in this publication was partially supported by the National Cancer Institute of the National Institutes of Health under the award for the Partnership of Native American Cancer Prevention U54CA143925, and by the National Institute on Deafness and Other Communication Disorders Grant R21DC016704-01A1. Publisher Copyright: {\textcopyright} 2020 Lippincott Williams and Wilkins. All rights reserved.",

year = "2020",

month = jun,

day = "1",

doi = "10.1097/MAO.0000000000002615",

language = "English (US)",

volume = "41",

pages = "e538--e547",

journal = "Otology and Neurotology",

issn = "1531-7129",

publisher = "Lippincott Williams and Wilkins",

number = "5",

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TY - JOUR

T1 - Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

AU - Bhatt, Ishan Sunilkuma

AU - Dias, Raquel

AU - Washnik, Nilesh

AU - Wang, Jin

AU - Guthrie, O'Neil

AU - Skelton, Michael

AU - Lane, Jeffery

AU - Wilder, Jason

N1 - Funding Information: The original research work described by Phillips et al. (22) was supported by the National Institute on Deafness and Other Communication Disorders Grant R21DC009296-01. The research reported in this publication was partially supported by the National Cancer Institute of the National Institutes of Health under the award for the Partnership of Native American Cancer Prevention U54CA143925, and by the National Institute on Deafness and Other Communication Disorders Grant R21DC016704-01A1. Publisher Copyright: © 2020 Lippincott Williams and Wilkins. All rights reserved.

PY - 2020/6/1

Y1 - 2020/6/1

N2 - Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.

AB - Introduction:This study aimed to investigate the association between candidate genetic variants and audiometric measures of noise-induced hearing loss (NIHL) in young musicians.Methods:The study analyzed a database by Phillips et al. (Feasibility of a bilateral 4000-6000 Hz notch as a phenotype for genetic association analysis. Int J Audiol 2015;54:645-52.) which included behavioral hearing thresholds, distortion-product otoacoustic emissions (DPOAE), tympanometric, and genetic data of 166 participants meeting the inclusion criteria. Nineteen single nucleotide polymorphisms (SNPs) in 13 cochlear genes previously associated with NIHL in factory workers were included in the present investigation. The average hearing threshold at 3000 and 4000 Hz (AHT) and average DPOAE signal to noise ratio (DPOAE SNR) in both ears were calculated.Results:The regression analyses showed that two SNPs-one in KCNE1 (rs2070358) and the other in CAT (rs12273124) revealed a statistically significant relationship with DPOAE SNR in both ears. Two SNPs in MYH14 and one in GJB4 revealed a significant association with DPOAE SNR in the left ear. Two SNPs in HSP70, one in CDH23 and one in KCNJ10 showed significant association with DPOAE SNR in the right ear. None of the included SNPs showed association with AHT in both ears.Conclusions:A genetic variant in KCNE1 was associated with the strength of the cochlear amplifier as assessed by DPOAE SNR. Musicians carrying causal genetic variants to NIHL might exhibit changes in their auditory functions early in the lifespan even when most subjects had their hearing thresholds within normal limits. These participants are likely to show the clinical manifestation of NIHL in the future if no preventive measures are applied.

KW - Catalase

KW - Estrogen-related receptor beta

KW - Gene association

KW - Music exposure

KW - Myosin heavy chain 14

KW - Noise-induced hearing loss

KW - Noise-induced hearing loss phenotype

KW - Nuclear receptor

KW - Potassium voltage-gated channel subfamily E regulatory subunit 1

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U2 - 10.1097/MAO.0000000000002615

DO - 10.1097/MAO.0000000000002615

M3 - Article

C2 - 32176153

AN - SCOPUS:85084695678

SN - 1531-7129

VL - 41

SP - e538-e547

JO - Otology and Neurotology

JF - Otology and Neurotology

IS - 5

ER -

Association Analysis of Candidate Gene Polymorphisms and Audiometric Measures of Noise-Induced Hearing Loss in Young Musicians

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