Antigen load and viral sequence diversification determine the functional profile of HIV-1-specific CD8⁺ T cells

Keyphrases

• 95% Confidence Interval 33%
• Acute Viral Infection 33%
• Antigen Loading 100%
• Antigen Persistence 33%
• Antigen-specific CD8+ T Cells 33%
• Antigenic Stimulation 33%
• Antiviral Immunity 33%
• CD8+ 100%
• CD8+ T Cells 100%
• CD8+ T Lymphocytes 33%
• Chemokines 33%
• Chronic HIV Infection 66%
• Conserved Epitopes 33%
• Cytotoxic T Lymphocyte Escape 33%
• Effector Function 33%
• Epitope 100%
• Epitope-specific 66%
• Escape mutation 33%
• Exhausted Phenotype 33%
• Functional Impairment 33%
• Functional Profile 100%
• HIV-1 Infection 33%
• Human Immunodeficiency Virus Type 1 (HIV-1) 100%
• In Vivo Selection 33%
• Load Sequence 100%
• Multiple Control Effectors 33%
• Multiple Cytokines 33%
• Ongoing Viral Replication 33%
• Persistent Viral Infection 33%
• Polyfunctional 66%
• Polyfunctional Profile 33%
• Primary HIV Infection 100%
• Programmed Cell Death Protein 1 (PD-1) 33%
• Responses to Antiretroviral Therapy 33%
• Sequence Diversification 100%
• Sequence of Therapy 33%
• Sequence Variation 33%
• Single-epitope 33%
• Specific Antigen 33%
• T Cell Response 100%
• Therapy Initiation 33%
• Viral Genome 100%
• Viral Replication 33%
• Viremia 33%
• Viremic 33%
• Virus-specific 66%
• Virus-specific CD8+ T Cells 33%
• Virus-specific T Cells 33%

Immunology and Microbiology

• Adaptive Immune System 12%
• Antigen 100%
• Antigen Specificity 12%
• Antigenic Stimulation 12%
• CD8+ T Lymphocyte 12%
• Chemokine 12%
• Cytokine 12%
• Cytotoxic T Cell 12%
• Cytotoxic T-Cell 100%
• Epitope 100%
• Human Immunodeficiency Virus 1 100%
• Infection 87%
• Infectious Disease 87%
• T Cell 12%
• Viral Replication 25%
• Viremia 12%
• Virus 62%
• Virus Infection 25%