Anaphylactoid response to Optison® and its effects on pulmonary function in two dogs

Yoshiki Yamaya, Kyuichi Niizeki, Jeannie Kim, Pauline Entin, Harrieth Wagner, Peter D. Wagner

Research output: Contribution to journalArticlepeer-review

18 Scopus citations


Two of 26 anesthetized dogs given the cardiac echo-enhancing agent Optison® showed anaphylactoid responses (AR) related to the human albumin component of this agent. The episodes of AR were self-limited, and could be reproduced by human albumin injection alone. Gas exchange was maintained by mechanical ventilation and 5 cm H2O PEEP, and dispersion of ventilation remained normal during AR despite severe hypotension. We suggest that: (1) pre-screening by measuring blood pressure response to intravenous injection of small doses of Optison®, and (2) availability of access to the airway in addition to emergency agents may be prudent preventive measures when Optison® is used in animals to enhance echocardiographic imaging.

Original languageEnglish (US)
Pages (from-to)1429-1432
Number of pages4
JournalJournal of Veterinary Medical Science
Issue number11
StatePublished - Nov 2004


  • Gas exchange
  • Human albumin
  • Hypotension

ASJC Scopus subject areas

  • General Veterinary


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