TY - JOUR
T1 - Analysis of maximal expiratory flow-volume curves in adult survivors of preterm birth
AU - Molgat-Seon, Yannick
AU - Dominelli, Paolo B.
AU - Peters, Carli M.
AU - Guenette, Jordan A.
AU - William Sheel, A.
AU - Gladstone, Igor M.
AU - Lovering, Andrew T.
AU - Duke, Joseph W.
N1 - Funding Information:
This research was supported by American Heart Association Scientist Development Grant no. 2280238 (A. T. Lovering), the American Physiological Society’s Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine (A. T. Lovering), a Medical Research Foundation of Oregon Early Clinical Investigator Award (J. W. Duke), and an Ohio University Research Committee Award (J. W. Duke). Additional funding was provided by the Natural Science and Engineering Research Council of Canada (NSERC) and the British Columbia Lung Association (BCLA). Y. Molgat-Seon and C. M. Peters were supported by graduate scholarships from NSERC. J. A. Guenette was supported by a Scholar Award from the Michael Smith Foundation for Health Research and a Canadian Institutes of Health Research Clinical Rehabilitation New Investigator Award. The funders had no role in the study design, data collection and analysis, or preparation of the manuscript.
Funding Information:
This research was supported by American Heart Association Scientist Development Grant no. 2280238 (A. T. Lovering), the American Physiological Society's Giles F. Filley Memorial Award for Excellence in Respiratory Physiology and Medicine (A. T. Lovering), a Medical Research Foundation of Oregon Early Clinical Investigator Award (J. W. Duke), and an Ohio University Research Committee Award (J. W. Duke). Additional funding was provided by the Natural Science and Engineering Research Council of Canada (NSERC) and the British Columbia Lung Association (BCLA). Y. Molgat-Seon and C. M. Peters were supported by graduate scholarships from NSERC. J. A. Guenette was supported by a Scholar Award from the Michael Smith Foundation for Health Research and a Canadian Institutes of Health Research Clinical Rehabilitation New Investigator Award. The funders had no role in the study design, data collection and analysis, or preparation of the manuscript.
Publisher Copyright:
Copyright © 2019 the American Physiological Society
PY - 2019/10
Y1 - 2019/10
N2 - Adult survivors of very preterm (≤ 32 wk gestational age) birth without (PRE) and with bronchopulmonary dysplasia (BPD) have variable degrees of airflow obstruction at rest. Assessment of the shape of the maximal expiratory flow-volume (MEFV) curve in PRE and BPD may provide information concerning their unique pattern of airflow obstruction. The purposes of the present study were to 1) quantitatively assess the shape of the MEFV curve in PRE, BPD, and healthy adults born at full-term (CON), 2) identify where along the MEFV curve differences in shape existed between groups, and 3) determine the association between an index of MEFV curve shape and characteristics of preterm birth (i.e., gestational age, mass at birth, duration of oxygen therapy) in PRE and BPD. To do so, we calculated the average slope ratio (SR) throughout the effort-independent portion of the MEFV curve and at increments of 5% of forced vital capacity (FVC) between 20 and 80% of FVC in PRE (n = 19), BPD (n =25), and CON (n = 20). We found that average SR was significantly higher in PRE (1.34 ± 0.35) and BPD (1.33 ± 0.45) compared with CON (1.03 ± 0.22; both P < 0.05) but similar between PRE and BPD (P = 0.99). Differences in SR between groups occurred early in expiration (i.e., 20 -30% of FVC). There was no association between SR and characteristics of preterm birth in PRE and BPD groups (all P > 0.05). The mechanism(s) of increased SR during early expiration in PRE/BPD relative to CON is unknown but may be due to differences in the structural and mechanical properties of the airways.
AB - Adult survivors of very preterm (≤ 32 wk gestational age) birth without (PRE) and with bronchopulmonary dysplasia (BPD) have variable degrees of airflow obstruction at rest. Assessment of the shape of the maximal expiratory flow-volume (MEFV) curve in PRE and BPD may provide information concerning their unique pattern of airflow obstruction. The purposes of the present study were to 1) quantitatively assess the shape of the MEFV curve in PRE, BPD, and healthy adults born at full-term (CON), 2) identify where along the MEFV curve differences in shape existed between groups, and 3) determine the association between an index of MEFV curve shape and characteristics of preterm birth (i.e., gestational age, mass at birth, duration of oxygen therapy) in PRE and BPD. To do so, we calculated the average slope ratio (SR) throughout the effort-independent portion of the MEFV curve and at increments of 5% of forced vital capacity (FVC) between 20 and 80% of FVC in PRE (n = 19), BPD (n =25), and CON (n = 20). We found that average SR was significantly higher in PRE (1.34 ± 0.35) and BPD (1.33 ± 0.45) compared with CON (1.03 ± 0.22; both P < 0.05) but similar between PRE and BPD (P = 0.99). Differences in SR between groups occurred early in expiration (i.e., 20 -30% of FVC). There was no association between SR and characteristics of preterm birth in PRE and BPD groups (all P > 0.05). The mechanism(s) of increased SR during early expiration in PRE/BPD relative to CON is unknown but may be due to differences in the structural and mechanical properties of the airways.
KW - Bronchopulmonary dysplasia
KW - Expiratory flow limitation
KW - Pulmonary function
KW - Slope ratio
KW - Ventilatory constraints
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U2 - 10.1152/AJPREGU.00114.2019
DO - 10.1152/AJPREGU.00114.2019
M3 - Article
C2 - 31433666
AN - SCOPUS:85073124972
SN - 0363-6119
VL - 317
SP - R588-R596
JO - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
JF - American Journal of Physiology - Regulatory Integrative and Comparative Physiology
IS - 4
ER -