@article{8d09822da0964eb199ae20fddcb070ec,
title = "Age-related patterns of cytomegalovirus antibodies accompanying Epstein-Barr virus co-infection",
abstract = "Objective: Cytomegalovirus (CMV) infection is associated with age-related chronic disease, and co-infection with Epstein-Barr virus (EBV) may compound disease risk. We aimed to assess the frequency of CMV infection and its relationship with age among EBV seropositive individuals in an Indigenous Amazonian population. Methods: We report concentrations of CMV and EBV antibodies in dried blood spot samples collected from 157 EBV positive Shuar participants aged 15–86 years (60.5% female) to assess CMV infection rate. We used logistic and linear regression models to examine associations among CMV, EBV, and age, adjusting for sex, geographic region, and body mass index. Results: Nearly two-thirds (63.1%) of EBV seropositive participants were also CMV seropositive. A 1-year increase in age was associated with 3.4% higher odds of CMV infection (OR [95% CI]: 1.034 [1.009–1.064], p =.012), but CMV antibody concentration was not significantly associated with age or EBV antibody concentration among co-infected individuals. Conclusions: Herpesvirus-related immunosenescence may be important to understanding chronic disease risk among Shuar. Future studies should further explore the role of co-infection in shaping age-related changes in immune function.",
author = "Barrett, {Tyler M.} and Liebert, {Melissa A.} and Eick, {Geeta N.} and Ridgeway-Diaz, {Julia G.} and Madimenos, {Felicia C.} and Blackwell, {Aaron D.} and Urlacher, {Samuel S.} and Sugiyama, {Lawrence S.} and Snodgrass, {J. Josh}",
note = "Funding Information: We thank the study participants and the Federaci{\'o}n Interprovincial de Centros Shuar. National Science Foundation (BCS-0824602; BCS-0925910); Ryoichi Sasakawa Young Leaders Fellowship Fund; Leakey Foundation; Wenner-Gren Foundation (7970); National Institutes of Health (5DP1OD000516–04, via Center for Evolutionary Psychology, University of California–Santa Barbara); University of Oregon (Bray Fellowship; Center for Latino/a & Latin American Studies; Department of Anthropology; Williams Fellowship Undergraduate Award). Funding Information: Leakey Foundation; National Institutes of Health, Grant/Award Number: 5DP1OD000516‐04; National Science Foundation, Grant/Award Numbers: BCS‐0824602, BCS‐0925910; Ryoichi Sasakawa Young Leaders Fellowship Fund; University of Oregon, Grant/Award Numbers: Bray Fellowship, Center for Latino/a & Latin American Studies, Department of Anthropology, Williams Fellowship Undergraduate Award; Wenner‐Gren Foundation, Grant/Award Number: 7970 Funding information Funding Information: We thank the study participants and the Federaci{\'o}n Interprovincial de Centros Shuar. National Science Foundation (BCS‐0824602; BCS‐0925910); Ryoichi Sasakawa Young Leaders Fellowship Fund; Leakey Foundation; Wenner‐Gren Foundation (7970); National Institutes of Health (5DP1OD000516–04, via Center for Evolutionary Psychology, University of California–Santa Barbara); University of Oregon (Bray Fellowship; Center for Latino/a & Latin American Studies; Department of Anthropology; Williams Fellowship Undergraduate Award). Publisher Copyright: {\textcopyright} 2021 Wiley Periodicals LLC.",
year = "2022",
month = nov,
doi = "10.1002/ajhb.23713",
language = "English (US)",
volume = "34",
journal = "American Journal of Human Biology",
issn = "1042-0533",
publisher = "Wiley-Liss Inc.",
number = "11",
}