Ag K-edge EXAFS analysis of DNA-templated fluorescent silver nanoclusters: Insight into the structural origins of emission tuning by DNA sequence variations

Michael L. Neidig, Jaswinder Sharma, Hsin Chih Yeh, Jennifer S. Martinez, Steven D. Conradson, Andrew P. Shreve

Research output: Contribution to journalArticlepeer-review

72 Scopus citations

Abstract

DNA-templated silver nanoclusters are promising biological fluorescence probes due to their useful fluorescence properties, including tunability of emission wavelength through DNA template sequence variations. Ag K-edge EXAFS analysis of DNA-templated silver nanoclusters has been used to obtain insight into silver nanocluster bonding, size, and structural correlations to fluorescence. The results indicate the presence of small silver nanoclusters (<30 silver atoms) containing Ag-Ag bonds and Ag-N/O ligations to DNA. The DNA sequence used leads to differences in silver-DNA ligation as well as silver nanocluster size. The results support a model in which cooperative effects of both Ag-DNA ligation and variations in cluster size lead to the tuning of the fluorescence emission of DNA-templated silver nanoclusters.

Original languageEnglish (US)
Pages (from-to)11837-11839
Number of pages3
JournalJournal of the American Chemical Society
Volume133
Issue number31
DOIs
StatePublished - Aug 10 2011
Externally publishedYes

ASJC Scopus subject areas

  • Catalysis
  • Chemistry(all)
  • Biochemistry
  • Colloid and Surface Chemistry

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