Advancing Liver Cancer Prevention for American Indian Populations in Arizona: An Integrative Review

Timian M. Godfrey, Edgar A. Villavicencio, Kimberly Barra, Priscilla R. Sanderson, Kimberly Shea, Xiaoxiao Sun, David O. Garcia

Research output: Contribution to journalReview articlepeer-review

1 Scopus citations


Liver cancer is a highly fatal condition disproportionately impacting American Indian populations. A thorough understanding of the existing literature is needed to inform region-specific liver cancer prevention efforts for American Indian people. This integrative review explores extant literature relevant to liver cancer in American Indian populations in Arizona and identifies factors of structural inequality affecting these groups. The Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines informed the methodology, and a literature search was conducted in PubMed, EMBASE, CINAHL, and PsycInfo for articles including Arizona American Indian adults and liver disease outcomes. Seven articles met the inclusion criteria in the final review. Five of the studies used an observational study design with secondary analysis. One article used a quasiexperimental approach, and another employed a community-engagement method resulting in policy change. The results revealed a lack of empirical evidence on liver cancer prevention, treatment, and health interventions for American Indian populations in Arizona. Research is needed to evaluate the high rates of liver disease and cancer to inform culturally relevant interventions for liver cancer prevention. Community-engaged research that addresses structural inequality is a promising approach to improve inequities in liver cancer for American Indian people.

Original languageEnglish (US)
Article number3268
JournalInternational Journal of Environmental Research and Public Health
Issue number6
StatePublished - Mar 1 2022


  • Disease prevention
  • Health equity
  • Healthcare disparities
  • Liver cancer
  • Liver diseases
  • Native americans
  • Pre-ventative health services
  • Social determinants of health

ASJC Scopus subject areas

  • Pollution
  • Public Health, Environmental and Occupational Health
  • Health, Toxicology and Mutagenesis


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