A strain-based finite element model for calcification progression in aortic valves

Amirhossein Arzani, Mohammad R.K. Mofrad

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Calcific aortic valve disease (CAVD) is a serious disease affecting the aging population. A complex interaction between biochemicals, cells, and mechanical cues affects CAVD initiation and progression. In this study, motivated by the progression of calcification in regions of high strain, we developed a finite element method (FEM) based spatial calcification progression model. Several cardiac cycles of transient structural FEM simulations were simulated. After each simulation cycle, calcium deposition was placed in regions of high circumferential strain. Our results show the radial expansion of calcification as spokes starting from the attachment region, agreeing very well with the reported clinical data.

Original languageEnglish (US)
Pages (from-to)216-220
Number of pages5
JournalJournal of Biomechanics
Volume65
DOIs
StatePublished - Dec 8 2017

Keywords

  • Calcific aortic valve disease
  • Finite element method
  • Mechanical strain
  • Transient structural mechanics

ASJC Scopus subject areas

  • Biophysics
  • Biomedical Engineering
  • Orthopedics and Sports Medicine
  • Rehabilitation

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