TY - JOUR
T1 - A strain-based finite element model for calcification progression in aortic valves
AU - Arzani, Amirhossein
AU - Mofrad, Mohammad R.K.
N1 - Funding Information:
This work was supported by the American Heart Association (Award 16GRNT27630015 ).
Publisher Copyright:
© 2017 Elsevier Ltd
PY - 2017/12/8
Y1 - 2017/12/8
N2 - Calcific aortic valve disease (CAVD) is a serious disease affecting the aging population. A complex interaction between biochemicals, cells, and mechanical cues affects CAVD initiation and progression. In this study, motivated by the progression of calcification in regions of high strain, we developed a finite element method (FEM) based spatial calcification progression model. Several cardiac cycles of transient structural FEM simulations were simulated. After each simulation cycle, calcium deposition was placed in regions of high circumferential strain. Our results show the radial expansion of calcification as spokes starting from the attachment region, agreeing very well with the reported clinical data.
AB - Calcific aortic valve disease (CAVD) is a serious disease affecting the aging population. A complex interaction between biochemicals, cells, and mechanical cues affects CAVD initiation and progression. In this study, motivated by the progression of calcification in regions of high strain, we developed a finite element method (FEM) based spatial calcification progression model. Several cardiac cycles of transient structural FEM simulations were simulated. After each simulation cycle, calcium deposition was placed in regions of high circumferential strain. Our results show the radial expansion of calcification as spokes starting from the attachment region, agreeing very well with the reported clinical data.
KW - Calcific aortic valve disease
KW - Finite element method
KW - Mechanical strain
KW - Transient structural mechanics
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U2 - 10.1016/j.jbiomech.2017.10.014
DO - 10.1016/j.jbiomech.2017.10.014
M3 - Article
C2 - 29100595
AN - SCOPUS:85033667816
SN - 0021-9290
VL - 65
SP - 216
EP - 220
JO - Journal of Biomechanics
JF - Journal of Biomechanics
ER -