@article{3ff854cb7aaf458da8915eae14163491,
title = "A Quantitative Assessment of Staphylococcus aureus Community Carriage in Yuma, Arizona",
abstract = "Background. Disease control relies on pathogen identification and understanding reservoirs. Staphylococcus aureus infection prevention is based upon decades of research on colonization and infection, but diminishing returns from mitigation efforts suggest significant knowledge gaps. Existing knowledge and mitigation protocols are founded upon culture-based detection, with almost no information about pathogen quantities. Methods. We used culture and a quantitative polymerase chain reaction assay on samples from 3 body sites to characterize colonization more comprehensively than previous studies by describing both prevalence and pathogen quantity. Results. We show a much higher overall prevalence (65.9%) than previously documented, with higher quantities and prevalence associated with the nares, non-Hispanic males (86.9%), and correlating with colonization in other body sites. These results suggest that research and clinical practices likely misclassify over half of colonized persons, limiting mitigation measures and their impact. Conclusions. This work begins the process of rebuilding foundational knowledge of S aureus carriage with more accurate and wholistic approaches.",
keywords = "carriage of S aureus, culturing S aureus, detection of S. aureus, quantitative carriage, saQuant",
author = "Benjamin Russakoff and Colin Wood and Lininger, {Monica R.} and Barger, {Steven D.} and Trotter, {Robert T.} and Sara Maltinsky and Mimi Mbegbu and Briana Coyne and Yag{\"u}e, {David Panisello} and Shari Kyman and Kara Tucker-Morgan and Kathya Ceniceros and Cristina Padilla and Kevin Hurtado and Ashley Menard and Francisco Villa and Wayment, {Heidi A.} and Crystal Hepp and Tara Furstenau and Viacheslav Fofanov and Liu, {Cindy M.} and Pearson, {Talima R.}",
note = "Funding Information: Financial support. This work was funded by the NAU Southwest Health Equity Research Collaborative, which is funded by the National Institute on Minority Health and Health Disparities at the National Institutes of Health (Grant U54MD012388). Funding was also received from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (Grant R15AI156771). Funding Information: This work would not have been possible without the support from the Regional Center for Border Health in Somerton, Arizona. We are grateful to the many field surveyors from Northern Arizona University (NAU) and the Regional Center for Border Health who recruited, sampled, and collected data from participants. This work was funded by the NAU Southwest Health Equity Research Collaborative, which is funded by the National Institute on Minority Health and Health Disparities at the National Institutes of Health (Grant U54MD012388). Funding was also received from the National Institute of Allergy and Infectious Diseases at the National Institutes of Health (Grant R15AI156771). Publisher Copyright: {\textcopyright} The Author(s) 2022.",
year = "2023",
month = may,
day = "1",
doi = "10.1093/infdis/jiac438",
language = "English (US)",
volume = "227",
pages = "1031--1041",
journal = "Journal of Infectious Diseases",
issn = "0022-1899",
publisher = "Oxford University Press",
number = "9",
}