@article{7774e676bb6441e2a428f0e143ee0bd2,
title = "A mouse model of binge alcohol consumption and Burkholderia infection",
abstract = "Binge drinking, an increasingly common form of alcohol consumption, is associated with increased mortality and morbidity; yet, its effects on the immune system's ability to defend against infectious agents are poorly understood. Burkholderia pseudomallei, the causative agent of melioidosis can occur in healthy humans, yet binge alcohol use is progressively being recognized as a major risk factor. Although our previous studies demonstrated that binge alcohol exposure results in reduced alveolar macrophage function and increased Burkholderia virulence in vitro, no experimental studies have investigated the outcomes of binge alcohol on Burkholderia spp. infection in vivo.",
author = "Victor Jimenez and Ryan Moreno and Erik Settles and Currie, {Bart J.} and Paul Keim and Monroy, {Fernando P.}",
note = "Funding Information: This study was made possible by funding from the US Department of Defense Chemical and Biological Defense Program through the Defense Threat Reduction Agency (grant ID HDTRA1-14-C-0022; www.dtra.mil/). The funder had no role in study design, data collection and analysis, decision to publish, or preparation of the manuscript. We thank Northern Arizona University{\textquoteright}s animal facility veterinarian and staff for providing guidance and training. We thank research associates at The Pathogen and Microbiome Institute and The Monroy lab at NAU for guidance and research support. In addition, we thank Dr. Nathan Nieto, from the Biology Department at NAU for helpful suggestions. Publisher Copyright: {\textcopyright} 2018 Jimenez et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.",
year = "2018",
month = nov,
doi = "10.1371/journal.pone.0208061",
language = "English (US)",
volume = "13",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "11",
}