A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment

Koushik Ghosh; Katherine C. Elbert; Eva Rose M. Balog; Jennifer S. Martinez; Reginaldo C. Rocha

doi:10.1007/s00775-018-1580-6

A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment

Koushik Ghosh, Katherine C. Elbert, Eva Rose M. Balog, Jennifer S. Martinez, Reginaldo C. Rocha

Research output: Contribution to journal › Article › peer-review

3 Scopus citations

Abstract

An optically active metallo-polymer assembly is demonstrated via conjugation of a genetically engineered elastin-like polypeptide (ELP) and a ruthenium(II) polypyridyl complex. By taking advantage of the phase transition of ELPs in water, photophysical properties of the resultant conjugate are investigated for both phases, below and above the critical transition temperature. Upon coacervation, the luminescence of the metallo-ELP is greatly enhanced as a consequence of local effects on the metal–ligand luminophore. These findings open a possibility to harness the temperature control of stimuli-responsive properties of biopolymers.

Original language	English (US)
Pages (from-to)	1153-1157
Number of pages	5
Journal	Journal of Biological Inorganic Chemistry
Volume	23
Issue number	7
DOIs	https://doi.org/10.1007/s00775-018-1580-6
State	Published - Oct 1 2018
Externally published	Yes

Keywords

Bioconjugation
Elastin-like polymers
Luminescence
Metal complex
Optical biomaterials

ASJC Scopus subject areas

Biochemistry
Inorganic Chemistry

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10.1007/s00775-018-1580-6

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title = "A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment",

abstract = "An optically active metallo-polymer assembly is demonstrated via conjugation of a genetically engineered elastin-like polypeptide (ELP) and a ruthenium(II) polypyridyl complex. By taking advantage of the phase transition of ELPs in water, photophysical properties of the resultant conjugate are investigated for both phases, below and above the critical transition temperature. Upon coacervation, the luminescence of the metallo-ELP is greatly enhanced as a consequence of local effects on the metal–ligand luminophore. These findings open a possibility to harness the temperature control of stimuli-responsive properties of biopolymers.",

keywords = "Bioconjugation, Elastin-like polymers, Luminescence, Metal complex, Optical biomaterials",

author = "Koushik Ghosh and Elbert, {Katherine C.} and Balog, {Eva Rose M.} and Martinez, {Jennifer S.} and Rocha, {Reginaldo C.}",

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doi = "10.1007/s00775-018-1580-6",

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T1 - A metallo-biopolymer conjugate of elastin-like polypeptide

T2 - photoluminescence enhancement in the coacervate microenvironment

AU - Ghosh, Koushik

AU - Elbert, Katherine C.

AU - Balog, Eva Rose M.

AU - Martinez, Jennifer S.

AU - Rocha, Reginaldo C.

PY - 2018/10/1

Y1 - 2018/10/1

N2 - An optically active metallo-polymer assembly is demonstrated via conjugation of a genetically engineered elastin-like polypeptide (ELP) and a ruthenium(II) polypyridyl complex. By taking advantage of the phase transition of ELPs in water, photophysical properties of the resultant conjugate are investigated for both phases, below and above the critical transition temperature. Upon coacervation, the luminescence of the metallo-ELP is greatly enhanced as a consequence of local effects on the metal–ligand luminophore. These findings open a possibility to harness the temperature control of stimuli-responsive properties of biopolymers.

AB - An optically active metallo-polymer assembly is demonstrated via conjugation of a genetically engineered elastin-like polypeptide (ELP) and a ruthenium(II) polypyridyl complex. By taking advantage of the phase transition of ELPs in water, photophysical properties of the resultant conjugate are investigated for both phases, below and above the critical transition temperature. Upon coacervation, the luminescence of the metallo-ELP is greatly enhanced as a consequence of local effects on the metal–ligand luminophore. These findings open a possibility to harness the temperature control of stimuli-responsive properties of biopolymers.

KW - Bioconjugation

KW - Elastin-like polymers

KW - Luminescence

KW - Metal complex

KW - Optical biomaterials

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M3 - Article

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SN - 0949-8257

VL - 23

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EP - 1157

JO - Journal of Biological Inorganic Chemistry

JF - Journal of Biological Inorganic Chemistry

IS - 7

ER -

A metallo-biopolymer conjugate of elastin-like polypeptide: photoluminescence enhancement in the coacervate microenvironment

Abstract

Keywords

ASJC Scopus subject areas

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