Plant-based dietary patterns are associated with chronic disease risk reduction, prevention, and reversal. As such, the Nutritarian diet is a dietary plan grounded in the daily consumption of micronutrient-dense, plant-rich foods that satisfy nutrient needs with a corresponding improvement in overall health. The Nutritarian Women’s Health Study was a fully-online intervention that included supportive, automated email messages, with participants self-reporting dietary adherence and anthropometric measurements quarterly. Changes in Body Mass Index (BMI) were not significant. The groups with the lowest baseline Waist-to-Height-Ratio (WHtR) showed an initial increase followed by a decrease. Responses related to dietary adherence showed that most participants easily consumed greens, beans, onions/garlic, berries, and seeds, avoided animal products, alcohol, and refined foods, but had difficulty with regularly consuming mushrooms and tomatoes. A midpoint questionnaire revealed participants consumed an overwhelming amount of their meals/snacks according to the dietary plan and about half found it easy/very easy to eat strictly Nutritarian. A large majority reported a positive change in health from participating in the study. The barriers to following the dietary plan include a busy lifestyle and the opposing views/pressures from friends, family, co-workers, and/or spouse/partner. It is important to evaluate this fully-online approach when considering future interventions.